过刊浏览

钾通道阻断剂所致的蜗内直流电位改变

王坚, 李倩虹, 董维嘉, 陈继生

南京铁道医学院听觉生理研究室. 南京 210009

摘要

该实验采用耳蜗外淋巴灌流技术,观察了四氨基吡啶(4-AP)、四乙基铵(TEA)以及奎宁等不同钾通道阻断剂对豚鼠蜗内直流电位(EP)的影响。发现快钾通道阻断剂4-AP对EP无明显影响,但可改变强噪声所致EP改变的形式。TEA与奎宁则可减少负相EP(N-EP)的绝对值。实验结果提示耳蜗内有不同类型的钾离子通道存在并各具有不同的生理意义。

关键词： 蜗内直流电位; 钾离子通道阻断剂

Changes in endocochlear potential induced by potassium-channel blockers

Wang Jianli, Qian Hong, Dong Weijia, Chen Jisheng

Department of Physiology, Nanjing Bailung Medical College. Nanjing 210009, China

Abstract

The effect of various potassium-channel blockers，4-aminopyridin(4-AP)，te
traethylaminonium (TEA) and quinine，on the endocochlear potential(EP) was studied in perfused guinea pig inner ears. The fast K~(+)-channel blocker，4-AP，did not alter EP but changed its'response model to intense noise exposure. While TEA and quinine significantly reduced the amplitude of negative component of EP (N-EP)，comparing with a relatively smaller increase in general EP (G-EP).The results indicated the exis tance of different K~(+)-channels with different physiological functions.

Key words: Engocochlear potential;Potassium-channel blockers

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

王坚, 李倩虹, 董维嘉, 陈继生. 钾通道阻断剂所致的蜗内直流电位改变[J]. 生理学报 1993; 45 (1): .

Wang Jianli, Qian Hong, Dong Weijia, Chen Jisheng. Changes in endocochlear potential induced by potassium-channel blockers. Acta Physiol Sin 1993; 45 (1): (in Chinese with English abstract).