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#kappa#-阿片受体激动通过激活KATP通道对大鼠腹主动脉产生舒张作用

裴建明, 陈迈, 王跃民, 文竣, 朱运龙

第四军医大学生理学教研室，西京医院心脏内科，物理教研室，陕西， 西安 710032

摘要

为观察U50 ,488 H(选择性K阿片受体激动剂)对大鼠腹主动脉的舒张作用，并探讨其机制，实验采用离体血管灌流实验，测定血管张力的改变。结果显示:(1) U50 ,488 H对大鼠腹主动脉具有明显的舒张作用;(2) U50,
488H对大鼠腹主动脉的舒张效应部分依赖于内皮细胞的存在;(3)优降糖和格列甲嗦可明显抑制U50 ,488 H对大鼠腹主动脉的舒张作用;( 4) U50 ,488 H的舒张血管效应与M受体、R受体、前列腺素及NO无关。结果表明，U50 ,488H是一种有效的扩血管物质，其舒张血管的效应具有内皮依赖性，且与KATP通道有密切关系。

关键词： 生理学; #Kappa#-阿片受体; 主动脉环灌流; 大鼠; KATP通道

#kappa#- Opioid receptor stimutation corntributes to aortic artery dilation through activation of K_(ATP) channel in the rats

PEI Jian Ming, Chen Mai, WANG Yao- Min, WEN Jun , Zhu Yunlong

Department of Physiology，Department of Cardiology，Xijing Hospital，and 3 Department of Physics，The Fourth Military Medical University, Xian 710032-

Abstract

To investigate the relaxation effect and underlying mechanism of U50 ,488 H(a selective K-opioid receptor agonist) on aorta in the rat，isolated aortic ring was perfused and the tension of the vessel was measured.It was shown:(1)K-
opioid receptor stimulation with U50 ,488H relaxed rat aorta dose-dependently;(2) the relaxation effect of U50， 488H on aorta was partially endothelium-dependent;(3) the relaxation effect of U50， 488H was significantly attenuated in the presence of glybenclamide and glipizide，two ATP-sensitive K` channel(KATP) blockers;and(4) the relaxation effect of U50，488H on vessel bore no relationship to muscariniC receptor，[r adrenoceptor，prostaglandin and nitric oxide(NO).These results indicate that K-opioid receptor stimulation with U50， 488H relaxes the aortic artery at least partially via KATP channel in
the rat.

Key words: hysiology;#kappa#-opioid receptor;aortic ring perfusion;Rat;KATP channel

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引用本文：

裴建明, 陈迈, 王跃民, 文竣, 朱运龙. #kappa#-阿片受体激动通过激活KATP通道对大鼠腹主动脉产生舒张作用[J]. 生理学报 2003; 55 (1): .

PEI Jian Ming, Chen Mai, WANG Yao- Min, WEN Jun , Zhu Yunlong. #kappa#- Opioid receptor stimutation corntributes to aortic artery dilation through activation of K_(ATP) channel in the rats. Acta Physiol Sin 2003; 55 (1): (in Chinese with English abstract).