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肾素一血管紧张素系统 —应激激素反应系统

万瑜, 杨钢, 万曙霞, 杨波, 尹艳茹, 席正雄

(湖北医科大学生理教研室，武汉430071)

摘要

各种急性与慢性应激时，循环血中及脑、心血管、肾上腺等组织中血管紧张素B (AⅡ)显著增多;人剧烈运动后血浆AⅡ与皮质醇一样均剧烈增加，在慢性应激性高血压动物循环及组织中，AⅡ含量持续地增高。还发现高浓度AⅡ对肾上腺糖皮质激素的分泌有直接的刺激作用，而组织Al增多又受肾上腺素能a受体的激发。根据近年来的系列工作，并结合文献，我们认为AⅡ是一种重要的应激激素;肾素一血管紧张素系统是一个应激激素反应系统;它与经典的应激激素反应系统，下丘脑-垂体-肾上腺皮质系统及交感-肾上腺髓质系统也存在着密切的关系。

关键词： 血管紧张素; 应激; 肾素--血管紧张素系统; 皮质醇; 下丘脑--垂体--肾上腺皮质系统; 交感--肾上腺髓质系统; 应激激素反应系统

RENIN-ANGIOTENSION SYSTEM —STRESS HORMONE RESPONSE SYSTEM

Wan Yu, Yang Gang, WAN SHU-XIA, YANG BO, PING YAN-RU , XI ZHENG-XIONG

(Department of Physiology, Hubei Medical University, Wuhan 430071)

Abstract

Angiotensin B (A Ⅱ)was significantly increased in both acutely and chronically stressed animals as found in brain，heart，blood vessels and adrenal glands. After running a race，the plasma A } contents of sportsmen similar to cortisol increased marked1y too. In the chronical stress-hypertensive animals，the contents of circulating A Ⅱ and tissue A Ⅱ were increased quite lastingly. It was also found that the high concentration
of A Ⅱ may stimulate the adrenal gland secreting glucosteroid，and increase of tissue A ff may be faciliated by the activation of beta adrenergic receptors. On basis of the above finding，we tend to assume that A IC is a stress hormone and the renin angiotension system (RAS) is a stress hormone responses system. Morever there exists a close relation between RAS and two classic stress hormone response systems, i. e. the hypothalamus-pituitary-adrenal cortex system and the sympathetic-adrenal medulla system.

Key words: angiotensin;Stress;renin-angiotensin-system;Cortisol;hypothalamuspituitary adrenal cortex;sympathetic-adrenal medulla system;stress hormone responses system

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引用本文：

万瑜, 杨钢, 万曙霞, 杨波, 尹艳茹, 席正雄. 肾素一血管紧张素系统 —应激激素反应系统[J]. 生理学报 1996; 48 (6): .

Wan Yu, Yang Gang, WAN SHU-XIA, YANG BO, PING YAN-RU , XI ZHENG-XIONG. RENIN-ANGIOTENSION SYSTEM —STRESS HORMONE RESPONSE SYSTEM. Acta Physiol Sin 1996; 48 (6): (in Chinese with English abstract).