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三种自然刺激对家兔颈动脉体化学感受器活动的影响

庞雷, 苗智慧, 王燕, 凌董力

(河北省医学科学院生理研究室，石家庄050021)

摘要

在游离灌流的颈动脉体窦神经标本，观察了PO_(2)降低、PCO_(2)增加和PH降低对化学感受性单位放电的影响。共记录了32个有自发放电的化学感受性单位对三种自然刺激的反应。所得结果如下:(1)只对PO_(2),降低有反应的化学感受性单位(对PCO:增加及PH降低均无反应)有10例(占总数的310%)，对三种自然刺激均有反应的化学感受性单位有9例(占280o)，对PO_(2)降低和PCO:增加有反应的化学感受性单位有9例(占280%)，对PO_(2)降低和PH降低两种刺激有反应的化学感受性单位有3例(占90%)，另有一例只对PH降低有反应。(2)不同的自然刺激对化学感受性单位放电频率影响不一致。PO:降低使放电频率增加最多，其次是PCO_(2)增加，作用最弱的是PH降低。根据以上结果，似可认为，在颈动脉体中存在着不同生理特性的化学感受性单位,它们对PO_(2) 9 PCOZ或PH有不同的敏感性。

关键词： 氧分压; 二氧化碳分压; 酸度; 颈动脉体化学感受器; 传人单位放电

EFFECTS OF DIFFERENT NATURAL STIMULANTS ON THE ACTIVITY OF THE RABBITS' CAROTID CHEMORECEPTOR

Pang Lei, MIAO ZHI-HUI, WANG YAN-LING , DONG LI

(Department of Physiology, Hebm Academy of Medical Sciences, Shijiazhuang 050021)

Abstract

The effects of different natural stimulants on the afferent unit discharge of rabbit carotid chemoreceptors were studied in the in vitro carotid body- sinus nerve preparation. A total of 32 chemoreceptive units were recorded. The results were as follows:(1)Of the 32 units，10 (31%)showed chemosensory responses only to POZ decrease;9 (28%)to all stimulants (P02 decrease，PC02 increase and pH decrease);9 (280o)to POZ decrease and PC02 increase;3(9%)to PO_(2) decrease and pH decrease;only one to pH decrease. (2) The potency of the three natural stimulants in eliciting the changes in intensity of discharge showed a decreasing order as follows:POZ decrease>PC02
increase>pH decrease. The above results suggest that the carotid body may contain only one or a combination of 2 or 3 kinds of chemoreceptors respectively sensitive to decrease POZ to increase PC0_(2 )or decrease pH.

Key words: PO_(2);PC0_(2);pH;Carotid chemoreceptor;afferent unit discharge

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引用本文：

庞雷, 苗智慧, 王燕, 凌董力. 三种自然刺激对家兔颈动脉体化学感受器活动的影响[J]. 生理学报 1996; 48 (6): .

Pang Lei, MIAO ZHI-HUI, WANG YAN-LING , DONG LI. EFFECTS OF DIFFERENT NATURAL STIMULANTS ON THE ACTIVITY OF THE RABBITS' CAROTID CHEMORECEPTOR. Acta Physiol Sin 1996; 48 (6): (in Chinese with English abstract).