过刊浏览

交感传出在大鼠糖尿病性痛过敏中的作用

刘健, 王克模, 何丽珍, 曹东元

(西安医科大学脑和神经研究室，西安710061)

摘要

交感传出和前列腺素(PGs)在周围神经不全损伤和炎症所引起的痛过敏中起重要作用，它们对糖尿病性痛过敏的影响尚不清楚。本工作先给大鼠腹腔注射6-经多巴胺(6-OHDA)损毁交感节后神经元((SPGNs)末梢后，再给予链脉佐菌素((STZ)以建立6-OHDA糖尿病大鼠模型，在连续4周的观察中这组大鼠伤害性爪回缩阐值(NPWT)和甩尾反射潜伏期(TFL)没有明显变化，而糖尿病组大鼠的痛阑显著降低，并伴有痛过敏。皮内注射NA可使糖尿病痛过敏大鼠的NPWT显著降低，酚妥拉明或育亨宾能使它们的NPWT明显升高，而呱哇嗦则不影响其NPWTo去甲肾上腺素(NA)和酚妥拉明不影响对照组大鼠的NPWT。给6-OHDA糖尿病组大鼠皮内注射NA或酚妥拉明都不能明显改变大鼠的NPWT, PGE1, PGE2和PGD2能使对照组和糖尿病组
大鼠的NPWT均明显降低。结果提示，SPGNs末梢参与糖尿病大鼠的痛过敏，NA作用于SPGNs
末梢的突触前a2一受体，刺激SPGNs末梢合成和释放PGs增多，后者作用于初级传入伤害感受器，引起大鼠产生痛过敏。

关键词： 交感传出; 前列腺素; 糖尿病; 痛过敏; 大鼠

EFFECTS OF SYMPATHETIC EFFERENT IN DIABETIC HYPERALGESIA IN RAT

Liu Jian, WANG KE-MO, HE LI-ZHEN , CAO DONG-YUAN

(Department of Brain and Nerve, Xian Medical University, Xian 710061)

Abstract

While sympathetic efferents and prostaglandins (PGs) play an important role in hyperalgesia of partial injury of peripheral nerves and inflammation，whether these are also involved in diabetic hyperalgesia is unknown. With intraperitoneal injection of 6hydroxydopamine(6- OHDA) to eliminate effects of sympathetic postganglionic neurons (SPGNs) terminals，a model of diabetic rats with infused 6-OHDA could be set up by injection of streptozotocin (STZ). Nociceptive paw-withdrawal threshold (NPWT)and tail flick latency (TFL) in 6-OHDA/diabetic rats were not changed significantly in the following four weeks. However，in diabetic group rats，pain threshold was decreased significantly and accompanied by development of hyperalgesia. NPWT was significantly decreased with noradrenaline(NA)in diabetic hyperalgesic rats and increased with phentolamine or yohimbine，but not by prazocin. In the control rats，
NPWT are not changed significantly by NA or phentolamine，and in 6OHDA/diabetic
rats，neither NA nor phentolamine also affected on NPWT significantly. However，NPWT may be significantly decreased by PGE1，PGE2 and PGD2 in both the control and the diabetic hyperalgesic rats.

Key words: sympathetic efferent;prostaglandins; diabetes;Hyperalgesia;rat

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

刘健, 王克模, 何丽珍, 曹东元. 交感传出在大鼠糖尿病性痛过敏中的作用[J]. 生理学报 1996; 48 (6): .

Liu Jian, WANG KE-MO, HE LI-ZHEN , CAO DONG-YUAN. EFFECTS OF SYMPATHETIC EFFERENT IN DIABETIC HYPERALGESIA IN RAT. Acta Physiol Sin 1996; 48 (6): (in Chinese with English abstract).