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肾上腺素对幼龄小鼠胸腺褪黑素受体的调节

赵瑛, 刘志民, 彭树勋

第二军医大学长征医院神经科，上海200003)；香港大学医学院生理系

摘要

应用放射配体结合法检测幼龄小鼠胸腺褪黑素受体(MR)，并以此为实验模型研究肾上腺素((E)对胸腺MR的影响及作用机制。结果表明，生理浓度的E即对胸腺MR有明显抑制作用，其抑制效应具时间依赖性及剂量依赖性。日一肾上腺素能受体拮抗剂普蔡洛尔可逆转此抑制效应cAMP对MR也有明显抑制作用，表明E对MR的抑制是通过日受体而实现的。这些结果提示，E在生理情况下即对胸腺MR有调节作用。

关键词： 胸腺; 褪黑紊受体; 肾上腺素; 酚妥拉明; 普蔡洛尔

REGULATION OF EPINEPHRINE ON MELATONIN RECEPTOR OF THE YOUNG MOUSE THYMUS

ZHAO YING , LIU ZHI-MIN, PANG SHIU-FUN

(Department of Neurology, Chang Zheng Hospital, Second Military Medical University, Shanghai 200003；(Department of Physidogy, Faculty of Medicine, University of Hong Kong))

Abstract

The melatonin binding sites in membrane preparations of the young mouse thymus were studies using [~(125)I] iodomelatonin as the radioligand. Effect of epinephrine (E)on melatonin receptor (MR) of young mouse thymus were investigated. Results:(1)E had inhibitory effect on MR of mouse thymus;(2)Propranolol could reverse the inhibitory effect of E，but phentolamin could not;(3) CAMP had inhibitory effect on MR. These results indicate that E has the inhibitory effect on MR of the mouse thymus and the effect was mediated by #beta# adrenergic receptor.

Key words: thymus; melatonin receptor;epinephrine;;

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引用本文：

赵瑛, 刘志民, 彭树勋. 肾上腺素对幼龄小鼠胸腺褪黑素受体的调节[J]. 生理学报 1996; 48 (5): .

ZHAO YING , LIU ZHI-MIN, PANG SHIU-FUN. REGULATION OF EPINEPHRINE ON MELATONIN RECEPTOR OF THE YOUNG MOUSE THYMUS. Acta Physiol Sin 1996; 48 (5): (in Chinese with English abstract).