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肾大部切除、高盐摄食对SD大鼠脑心房钠尿肽的影响

林善锬, 王世宣

(上海医科大学华山医院肾脏病科，上海200090)

摘要

为探讨脑内心房钠尿肽(ANP)的作用，本工作采用SD大鼠，用放射免疫方法测定3/4肾
大部切除与高盐摄食后脑内ANP的含量。结果表明，对照组大鼠脑内ANP分布广泛。3/4肾切
除大鼠每日饮水量，尿量均比对照组高(P<0. 05)，尿钠浓度低于对照组时，脑内ANP含量尽管略有增加，但10个核团(下丘脑室周核、弓状核、室旁核、视前室周核、中缝背核、尾壳核、杏仁核、脑桥背侧部、蓝斑和大脑皮质)ANP含量和对照组无明显差别((P>0. 05)。高盐摄食组每日饮水量和尿量均比对照组高，且尿钠浓度高于对照组，同时下丘脑室周核和弓状核ANP含量比对照组高((P<0. 05)。上述结果提示，大脑第三脑室前腹侧区(AV3V区)的ANP可能在水盐调节上发挥重要作用。

关键词： 心房钠尿肽; AV3V区

EFFECTS OF SUBTOTAL NEPHRECTOMY AND HIGH SALT INTAKE ON ATRIAL NATRIURETIC PEPTIDE IN THE BRAINS OF RATS

UN SHAN-YAN , WANG SHl-XUAN

(Department of Nephrology，Shanghai Medical University, Shanghai 200040)

Abstract

In order to explore the role of brain atrial natriuretic peptide (ANP) in regulating water and electrolytes，the changes of the ANP content of various brain areas in the status of high salt intake and in 3/4 nephrectomy rats. In control group，a wide distribution of ANP was observed in different areas of the brain. The amount of daily water intake and urine were larger，and urine sodium concentration was lower in the 3/ 4nephrectomy group than those in the control group (P<0. 05).In the ten nuclei we have studied，ANP content was not significantly different from that of the control (P>0. 05).In the high salt group，water intake，urine volume and urine sodium concentration were significantly higher than those in the control. In this group，brain ANP in-
creased in the periventricular nuclues (PVN) and arcute nucleus (Arc) (P<0. 05).The results indicate that ANP in anteroventral region of the third ventricle (AV3V)might play important role in the regulation of water and electolytes.

Key words: Atrial natriuretic peptide;anteroventral third ventricle

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引用本文：

林善锬, 王世宣. 肾大部切除、高盐摄食对SD大鼠脑心房钠尿肽的影响[J]. 生理学报 1996; 48 (5): .

UN SHAN-YAN , WANG SHl-XUAN. EFFECTS OF SUBTOTAL NEPHRECTOMY AND HIGH SALT INTAKE ON ATRIAL NATRIURETIC PEPTIDE IN THE BRAINS OF RATS. Acta Physiol Sin 1996; 48 (5): (in Chinese with English abstract).