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神经激肽A注人大鼠外侧网状核或中缝大核产生的镇痛效应

闰国平, 赵晏, 黄其鄂, 陈婉梅

(空军天津医院神经内科，天津300381)西安医科大学神经生理研究室，西安710061)

摘要

采用核团内微量注射的方法，以甩尾反射潜伏期(TFL)为痛闭指标，在浅麻状态下
的大鼠上，对神经激肤A (NKA)在外侧网状核(LRN)和中缝大核(NRM)中的作用作了探讨。
研究结果表明，NKA (0. 5 ug/0. 5 p1)注入LRN后的10 min内大鼠TFL明显延长(n=12, P<
0.001)，同样剂量NK^注入NRM后的5 min内，TFL也明显延长(n=13, P<0. 001)，提示NKA
可能是 LRN和NRM内参与痛觉的一种神经调质。

关键词： 神经激肽A; 外侧网状核; 中缝大核; 甩尾反射; 微t注射; 镇痛

ANALGESIC ACTION OF MICROINJECTION OF NEUROKININ A INTO THE LATERAL RETICULAR NUCLEUS AND NUCLEUS RAPHE MAGNUS IN RATS

YAN GUO-PING, Zhao Yan, HUANG QI-E, CHEN WAN-MEI

Air Force Tianjin Hospital, Tianjin 300381)； (Xi‘an Medical University, Xi‘an 710061)

Abstract

Using the microinjection technique，the analgesic effect of neurokinin A (NKA)microinjected into the lateral reticular nucleus(LRN)and nucleus raphe magnus (NRM) was investigated in lightly pentobarbital-anesthetized rats using tail flick latency (TFL) as an index. Microinjection of NKA (0. 5 #mu#g/0. 53mu#L) into LRN significantly increased TFL lasting for 10 min (n=12，P<0. 001).Microinjection of the same amount of NKA into NRM also produced evident increase in TFL for 5 min (n=13，P<0.001).The results indicate that NKA modulates pain reaction in both LRN and NRM in rats.

Key words: neurokinin A;lateral reticular nucleus;Nucleus raphe magnus;tail flick reflex;microinjection;analgesia

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引用本文：

闰国平, 赵晏, 黄其鄂, 陈婉梅. 神经激肽A注人大鼠外侧网状核或中缝大核产生的镇痛效应[J]. 生理学报 1996; 48 (5): .

YAN GUO-PING, Zhao Yan, HUANG QI-E, CHEN WAN-MEI. ANALGESIC ACTION OF MICROINJECTION OF NEUROKININ A INTO THE LATERAL RETICULAR NUCLEUS AND NUCLEUS RAPHE MAGNUS IN RATS. Acta Physiol Sin 1996; 48 (5): (in Chinese with English abstract).