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脑室注射白细胞介素2抑制脾交感神经活动

李德敏, 林树新

(第四军医大学基础部病理生理学教研室，西安710032)

摘要

应用电生理方法研究了中枢应用白细胞介素2 (interleukin-2, IL-2)对脾交感神经放电活动的影响。用urethane和、chloralose麻醉Sprague-Dawley大鼠，第三脑室微量注射基因重组人IL-2 300 U，观察到脾交感神经冲动数减少。在工L-2注射前后应用阿片受体阻断剂纳洛酮(naloxone, Nal)，均可阻断这种效应，但单独应用Nal对脾神经兴奋性没有影响。实验中未观察到工L-2对体温和动脉血压的影响，说明工L-2抑制脾神经电活动的作用不是通过对体温或血压的影响产生的。以上结果提示，IL-2可以在中枢神经系统通过某种由阿片受体介导的通路对交感神经系统的兴奋性产生影响。

关键词： :脑室注射; 白细胞介紊_2; 脾脏; 交感神经系统; 纳洛酮

INTRACEREBROVENTRICULAR INJECTION OF INTERLEUKIN- 2 INHIBITS SPLENIC SYMPATHETIC NERVE ACTIVITY

LI DE-MIN , LIN SHU-XIN

(Department of Pathophysiology, Fourth Military Medical University, Xi' an 710032)

Abstract

The effect of central administration of interleukin-2 (IL-2) on the splenic sympathetic nerve activity was studied. Intracerebro ventricular infusion of recombinant human IL-2 (300 U/rat) elicited marked long term(>120 min) decrease in the electrical activity of the splenic nerve without altering blood pressure and body temperature.This splenic effect could be blocked by prior or post treatment with an opioid antagonist naloxone(1 mg/kg，iv).Naloxone alone injected intravenously had no effect on the
splenic nerve activity. These results imply that the inhibitory effect of intracerebral IL-2 on splenic sympathetic nerve activity is mediated by opioid receptors.

Key words: injections;intraventricular;interleukin-2;spleen; sympathetic nervous system

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引用本文：

李德敏, 林树新. 脑室注射白细胞介素2抑制脾交感神经活动[J]. 生理学报 1996; 48 (5): .

LI DE-MIN , LIN SHU-XIN. INTRACEREBROVENTRICULAR INJECTION OF INTERLEUKIN- 2 INHIBITS SPLENIC SYMPATHETIC NERVE ACTIVITY. Acta Physiol Sin 1996; 48 (5): (in Chinese with English abstract).