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大鼠最后区内微量注射血管紧张素II 对肾脏排钠的影响

彭艾, 林善#yan#, 郝传明, 李鹏, 周江华

上海医科大学华山医院肾脏病科，上海200090)

摘要

已知最后区(area postrema, AP)存在血管紧张素B (A B)受体，并可感受血中AB水平的变化。本文采用微量注射AB于AP的方法，观察了AP和肾功能的关系。结果:AP内微量注射
A d (2, 20 ng)引起肾小球滤过率(GFR)，肾血浆流量(RPF)，尿钠排泄(U,,, V)的增加(P
<0. 05)。该作用可被AP内微量注射AB拮抗剂saralasin或切断肾神经所阻断((P<0. 05)。而静脉注射saralasin却不能阻断该作用。微量注射AB于孤束核后GFR, RPF, UN,V无变化((P>0.05)。上述结果表明AB诱导肾血流动力学和尿钠的排泄改变可能是通过AP的。

关键词： 最后区; 血管紧张素l; 肾功能; 微t注射

EFFECT OF MICROINJECTION OF ANGIOTENSIN II INTO AREA POSTREMA ON RENAL SODIUM EXCRETIOT

PENG AI, LIN SHAN-YAN, HAO Chuan-Ming, LI PENG, ZHOU JIANG-HUA

Division of Nephrology, Huashan Hospital Shanghai Medical University, Shanghai 200040；Department of Physiology，Shanghai Medical University, Shanghai 200032))

Abstract

It has been "known that area postrema (AP) possesses angiotensin I (A I)receptors and senses directly the change of blood A ff level. The effect of microinjection of A I into the AP on renal sodium excretion was studied in the present investigation Our experimental results show that microinjection of A 1 (2，20 ng) increases GFR，RPF and UNBV (P<0. 05).These changes can be abolished by A I antagonist，saralatin and renal denervation (P<0. 05).However microinjection of A 1 (20 ng) into NTS pr叫uces no such changes. These results strongly suggest that the A I induced changes of renal hemodynamics and urine sodium excretion are mediated through AP.

Key words: area postrema;angiotensin B;renal function; microinjection

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引用本文：

彭艾, 林善#yan#, 郝传明, 李鹏, 周江华. 大鼠最后区内微量注射血管紧张素II 对肾脏排钠的影响[J]. 生理学报 1996; 48 (5): .

PENG AI, LIN SHAN-YAN, HAO Chuan-Ming, LI PENG, ZHOU JIANG-HUA. EFFECT OF MICROINJECTION OF ANGIOTENSIN II INTO AREA POSTREMA ON RENAL SODIUM EXCRETIOT. Acta Physiol Sin 1996; 48 (5): (in Chinese with English abstract).