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妊娠早期胎盘绒毛中肾素活性及其分泌的研究

陈忠科, 焦丽红, 阎建设, 王红

中国科学院动物研究所计划生育生殖生物学国家重点实验室，北京100080；山东大学生命科学学院生物化学与分子生物学系，济南250100)

摘要

取人工流产的不同妊娠周龄的人妊娠早期胎盘绒毛组织，测定其肾素活性及其在离体培养条件下的肾素分泌，同时对组织中的血管紧张素I和I (angiotensin I and I，AI，AI)的含量进行测定。结果表明:人妊娠早期胎盘绒毛组织中的肾素活性较高，但随着妊娠周龄的增加，肾素活性明显降低;AI含量随着妊娠周龄的增加而显著增加，与肾素活性的变化趋势相反;离体培养的绒毛有分泌肾素的能力，分泌能力随着妊娠周龄的增加而增加;在绒毛组织提取液和离体培养液中均未检测到AI。提示人妊娠早期胎盘绒毛组织可能已存在着独立的肾素一血管紧张素系统。

关键词： 肾素; 血管紧张素; 妊娠; 胎盘绒毛

TISSUE CONCENTRATION AND SECRETION OF BENIN IN HUMAN PLACENTAL VILLI DURING EARLY PREGNANCY

CHEN ZHONG-KE, JIAO Li-HONG, YAN JIAN_SHE, WANG HONG

(State Key Laboratory of Reproductive Biology, Institute of Zoology, Academy Sinica, Beijing 100080；Department of Biochemistry and Molecular Biology, Life Science Faculty, Shandong Uniaaersity, Jiaurn 250100)

Abstract

In this study，tissue concentrations of renin and angiotensins in human placental villi during early pregnancy and contents of renin and angiotensin I (A I)secreted by cultured chorion were measured by radioimmunal assay (RIA).The results are as follows. During early pregnancy，the human chorion contains renin and A 1i .The activity of renin is much higher at 6th week of gestation，but as gestation proceeds，it decreases gradually，while A If shows somewhat increased change. The activity of renin secreted by cultured chorion can also be measured. A I in human placental villi can not be detected by RIA in chorion leaves or their culturing fluid. These results indicate that renin-angiotensin system may exist independently in human placental villi during
early pregnancy.

Key words: renin;angiotensin I andⅡ;Gestation;placental villi

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引用本文：

陈忠科, 焦丽红, 阎建设, 王红. 妊娠早期胎盘绒毛中肾素活性及其分泌的研究[J]. 生理学报 1997; 49 (4): .

CHEN ZHONG-KE, JIAO Li-HONG, YAN JIAN_SHE, WANG HONG. TISSUE CONCENTRATION AND SECRETION OF BENIN IN HUMAN PLACENTAL VILLI DURING EARLY PREGNANCY. Acta Physiol Sin 1997; 49 (4): (in Chinese with English abstract).