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脑内P物质在谷氨酸兴奋中央杏仁核引起的升压反应中的作用

吕贻春, 顾蕴辉, 梁翌, 王益光, 李利生, 谭璐

(北京医科大学生理系，北京100083)

摘要

脑内P物质((SP)能神经元及其轴突末梢和相应受体广泛分布在中央杏仁核(AC)及其投
射的重要升压区。本工作显示:(1)谷氨酸(Glu)兴奋AC或将SP分别注入AC投射区:蓝斑
(LC)、臂旁核(NPB )、中脑导水管周围灰质((PAG)或外侧下丘脑一弯窿周围区(LH/PF)均引
起升压反应;(2) LC, NPB, PAG或LH/PF内预先注入[D-Pro~(2), D-Phe~(7)', D-Trp~(9)-SP (SP拮剂)均能衰减谷氨酸兴奋AC引起的升压反应;(3)延髓头端腹外侧区(RVLM)内预先分别注射酚妥拉明、心得安或阿托品也能削弱AC升压反应，但GDEE (Glu拮抗剂)预处理无此效应。以上结果结合以往报道(LC由RVLM内#alpha##beta#-, M一受体，NPB由RVLM内。一受体，PAG则由RVLM内#alpha#和序受休介导其升压反应)表明AC发出的SP能投射纤维可直接作用于脑干升
压区(LC, NPB, PAG)-RVLM升压系统，也可作用于LH/PF，进而实现其升压反应。

关键词： 升压反应; 中央杏仁核; 外侧下丘脑; 脑干升压区; 大鼠

ROLE OF SUBSTANCE P IN PRESSOR RESPONSE OF CENTRAL AMYGDALOID NUCLEUS TO GLUTAMATE

LU YL-CHUM, GU (KU) YUN-Hui, LIANG Y1 , WANG Yi-GUANG

(Department of Physiology, Beijing Medical University , Beijing 100083)

Abstract

Substance P (SP)一immunoreactive cells and the axon terminals are widely distributed in the central amygdaloid nucleus (AC) and its important projection areas. The present study showed that(1)Excitation of the AC by glutamate (Glu) or injection of SP into the AC projection areas:locus coeruleus (LC)，nucleus parabrachialis (NPB)periaqueductal gray matter (PAG)or lateral hypothalamus- perifornical region (LH/PF)，all elicited pressor response.(2)Preinjection of DPDPDT (a SP antagonist) into bilateral LC，N PB，PAG or LH/PF could attenuate the AC pressor response to Glu.
(3) Intra-RVLM (rostral ventrolateral medulla)preinjection of either phentolamine，propranolol or atropine (but not GDEE，a Glu antagonist)could also reduce the AC pressor response. Taken together with our previous findings that the a-，冬，M-receptors in RVLM mediated the pressor response to LC excitation，a-receptors mediated the NPB pressor response，a- and (3-receptors mediated the PAG pressor response;these results indicate that the SPergic projections of the AC not only directly act upon the brainstem pressor areas (LC，NPB，PAG)一RVLM system，but also indirectly via the LH/PF act upon the brainstem pressor areas-RVLM system to induce the pressor response.

Key words: :pressor response;central arnygdaloid nucleus;;;

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引用本文：

吕贻春, 顾蕴辉, 梁翌, 王益光, 李利生, 谭璐. 脑内P物质在谷氨酸兴奋中央杏仁核引起的升压反应中的作用[J]. 生理学报 1997; 49 (4): .

LU YL-CHUM, GU (KU) YUN-Hui, LIANG Y1 , WANG Yi-GUANG. ROLE OF SUBSTANCE P IN PRESSOR RESPONSE OF CENTRAL AMYGDALOID NUCLEUS TO GLUTAMATE. Acta Physiol Sin 1997; 49 (4): (in Chinese with English abstract).