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肠淋巴液对大鼠血压的影响

张静, 刘艳凯, 姜生, 葛琳, 史满金, 张利明

张家口医学院病理生理教研室，张家(1 070029)

摘要

该文用引流及输入肠淋巴液的方法，研究了肠淋巴液对人鼠血压的影响。结果如下:(1)经肠淋巴管插管引流肠淋巴液的大鼠，自引流后!50 min起，血压显著低于假手术组((P<0. 05 ) .(2)在丢失肠淋巴液同时，补充等量白蛋白或脂肪乳，仍不能防止血压下降，但肠淋巴管一颈静脉搭桥大鼠，在4h观察过程中，血压不出现显著降低。(3)重症失血性休克大鼠输入小量肠淋巴液后，血压显著回升，其血压水平及存活时间显著优于对照组((P<0. 05 --0. 01 )。上述结果表明，淋巴系统除了已知的组织液回流途径及维持血容量等功能外，肠淋巴液可能还具有维持血压的重要作用。

关键词： 肠淋巴液; 血压; 休克; 调节

EFFECT OF INTESTINAL LYMPH ON BLOOD PRESSURE OF RAT

ZHANG JING, LIU YAN-KAI, JIANG HUA, GE LIN, SHI MAN-JIN, ZHANG LI-MING

(Department of Pathophysiology, Zhangjiakou Medical College, Zhangjiakou 075029)

Abstract

The effect of intestinal lymph on blood pressure in rats was observed by the methods of lymph drainage and lymph infusion. The results obtained are as follows:(1)After 150 min of the lymph drained through the cannula of intestinal lymph duct，the blood pressure was significantly lower than that of the sham group (P<0. 05).(2) Equivalent albumin or intralipid infusion was not able to prevent the decrease in blood pressure when the lymph was lost. But in jugular-intestinal lymph duct shunt group，no significant blood pressure decrease could be seen during the drainage procedure for 4 h: (3) The blood pressure of rat with serious hemorrhagic shock could be increased significantly with a little amount of intestinal lymph infusion，and the rats survived longer than those of the control group (P<0. 05-0. 01).The above results suggest that the intestinal lymph may play an important role in maintenance of blood pressure，in addition to the known function of lymphatic system by returning tissue fluid to blood and maintaining circulating blood volume.

Key words: intestinal lymph;Blood pressure;shock;regulation

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引用本文：

张静, 刘艳凯, 姜生, 葛琳, 史满金, 张利明. 肠淋巴液对大鼠血压的影响[J]. 生理学报 1997; 49 (4): .

ZHANG JING, LIU YAN-KAI, JIANG HUA, GE LIN, SHI MAN-JIN, ZHANG LI-MING. EFFECT OF INTESTINAL LYMPH ON BLOOD PRESSURE OF RAT . Acta Physiol Sin 1997; 49 (4): (in Chinese with English abstract).