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乙酞胆碱减小猫外膝体中继细胞低闭值T一型钙电导

罗茹荪, S. M. Sherman

中国科学院上海脑研究所，上海200031

摘要

在离体猫丘脑脑片上观察了乙酞胆碱对外膝体中继神经元膜的低闭值T-型钙电导的影响。电流籍位和电压籍位实验结果都显示:将膜电位籍制到给药前的对照水平，排除了乙酸胆碱的去极化作用后，大多数(8200)外膝体神经元的低阂值钙电导仍然被乙酞胆碱所抑制。说明这种抑制作用独立于乙酞胆碱引起的膜电位变化，而是对低闭值T-型钙通道的直接作用。

关键词： 外膝体; 离子通道; T一型钙离子通道; 乙酰胆碱; 电压箝位

ACETYLCHOLINE DECREASES LOW THRESHOLD T-TYPE CALCIUM CONDUCTANCE OF RELAY CELLS IN THE CAT'S LATERAL GENICULATE NUCLEUS

LO Fu-SUN-, S. M. SHERMAN

Shanghm Brain Research Institute, Shanghai 200031

Abstract

The effect of acetylcholine (ACh) on the low threshold T-type Cal-- conductance of relay cells in the cat lateral geniculate nucleus (LGN) was studied using in vitre thalamic slices. Results from both current-clamp and voltage-clamp experiments showed that the low threshold Ca2+ conductance was inhibited by ACh in most (82%)of the LGN neurons tested，even when the membrane potential was clamped to the control level.This inhibitory effect was independent of the changes in membrane potential by ACh.Therefore，ACh might exert a direct action on low threshold Call channels.

Key words: lateral geniculate nucleus;ion channels; T-type calcium conductance;acetylcholine voltage-clamp ;

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引用本文：

罗茹荪, S. M. Sherman . 乙酞胆碱减小猫外膝体中继细胞低闭值T一型钙电导[J]. 生理学报 1997; 49 (2): .

LO Fu-SUN-, S. M. SHERMAN. ACETYLCHOLINE DECREASES LOW THRESHOLD T-TYPE CALCIUM CONDUCTANCE OF RELAY CELLS IN THE CAT'S LATERAL GENICULATE NUCLEUS. Acta Physiol Sin 1997; 49 (2): (in Chinese with English abstract).