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心脏#beta#肾上腺素受体及其亚型随年龄而变化

李艳芳, 张幼怡, 异水梅, 韩启德

北京医科大学第三医院血管医学研究所，北京100083)

摘要

该文采用放射配体结合实验和离体左心房收缩功能实验观察了48周龄和10周龄Wistar y鼠心脏0肾上腺素受体(#beta#-AR)及其亚型的数量和功能的改变c结果表明:(1)心脏(#beta#-AR吃数量在48周龄大鼠较!0周龄大鼠下调约28%。且为#beta#1与#beta#2-AR同等程度下调;(2) 48周龄大鼠(#beta#1AR及其亚型对异丙肾上腺素的敏感性明显减弱;(3>在10周龄大鼠心脏介导收缩效应c(#beta#-AR的作用为主，而在48周龄人鼠心脏引起收缩效应则是#beta#1和#beta#2-AR作用相等;(4)心脏#beta#1和#beta#2-AR同时激动介导左心房正性变力效应时，在10周龄大鼠为两种亚型受体效应的正协同而铭周龄大鼠则为两种亚型受体效应的相加
摘(中)(600

关键词： 心脏; #beta#肾上腺素受体; 受体亚型; 年龄

ALTERATION OF CARDIAC#beta# ADRENOCEPTORS AND SUBTYPES WITH INCREASING AGE

LI YAN-FANG, ZHANG You-Yl, YI YONG-MEi

(Institute of Vascular Medicine, Third Hospital, Beijing Medical University, Beijing 100083)

Abstract

The alteration of cardiac #beta#-adrenoceptor#beta#AR and subtypes in Wistar rats of 48 and 10 weeks old were investigated by radioligand binding assay and functional determination of isolated perfused left atria. The results indicated that:(1)The density of cardiac total #Beta#-AR was downregulated about 28%in 48 weeks old rats as compared with rats of 10 weeks old for both#beta#1and #beta#2AR;(2) The sensitivity of #beta#-AR and subtypes to isoproterenol in isolated perfused atria was significantly lowered in rats of 48 weeks old.

Key words: heart;#beta#-adrenoceptor; receptor subtype;age

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引用本文：

李艳芳, 张幼怡, 异水梅, 韩启德. 心脏#beta#肾上腺素受体及其亚型随年龄而变化[J]. 生理学报 1997; 49 (2): .

LI YAN-FANG, ZHANG You-Yl, YI YONG-MEi. ALTERATION OF CARDIAC#beta# ADRENOCEPTORS AND SUBTYPES WITH INCREASING AGE. Acta Physiol Sin 1997; 49 (2): (in Chinese with English abstract).