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免颈迷走神经传人冲动抑制肾交感神经传出活动的延髓机制

苏军达, 黄仲荪, 王莎莉, 陆杰

(重庆医科大学生理教研室，重庆 四川 630046)

摘要

实验在63只戊巴比妥钠麻醉、制动和人工呼吸条件l的家兔身曰挂行。刺激颈部一侧迷走神经中枢端((CVN)引起肾交感神经传出放电((RSND)抑制反应，抑制时间为3. 6--0. 18 s。这种抑制时间的长短与动物当时CNS机能状态、交感神经活动的背景水平有关。通过记录延髓头端腹外侧区(RVL)和尾端腹外侧区(CVL)的细胞放电变化，表明CVN传入冲动可能是通过孤束核(NTS)引起CVL兴奋及RVL的抑制，从而使交感神经传出活动发生抑制

关键词： 交感神经放电; 迷走传人; 孤束核; 延髓头端腹外侧区; 延髓尾端腹外侧区

MEDULLARY MECHANISM OF THE INHIBITION ON RENAL SYMPATHETIC EFFERENT ACTIVITIES BY STIMULATION OF THE CERVICAL VAGAL AFFERENT NERVE IN RABBITS

SU JUN-DA, HUANG ZHONG-SUN, WANG SHA-LI , LU JIE

Department of Physiology Chongqing University of Medical Science Chongqing 630046)

Abstract

Experiments were performed on 63 rabbits anesthetized with pentobarbital，paralyzed with gallamine triethiodide and ventiled artifically. lpsilateral renal sympathetic nerve discharge (RSND)，unit discharges of rostra] ventrolateral medulla (RVL)，eaudal ventrolateral medulla (CVL) and blood pressure (BP) were recorded. The sympatho-inhibitory response were evoked by stimulation of the central end of vagal nerve (CVN)(731/788 exp.).The inhibitory duration is 3. 6士0.]85 s. The responses vary with the functional state of the CNS. The RSND inhibitory duration could be shortened or prolonged，depending on the excitatory background of RSND or the basal
sympathetic tonic activity. The results, indicate that CVN一induced inhibitory of RSND may be mediated，at least partly，by excitation of NTS and CVL，which results，in turn，in depressing RVL and final reduction of sympathetic efferent activity.

Key words: sympathetic nerve discharge;vagal afferents;Nucleus tractus solitarii;rostral ventrolatoral medulla;caudal ventrolateral medulla

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引用本文：

苏军达, 黄仲荪, 王莎莉, 陆杰. 免颈迷走神经传人冲动抑制肾交感神经传出活动的延髓机制[J]. 生理学报 1996; 48 (4): .

SU JUN-DA, HUANG ZHONG-SUN, WANG SHA-LI , LU JIE. MEDULLARY MECHANISM OF THE INHIBITION ON RENAL SYMPATHETIC EFFERENT ACTIVITIES BY STIMULATION OF THE CERVICAL VAGAL AFFERENT NERVE IN RABBITS . Acta Physiol Sin 1996; 48 (4): (in Chinese with English abstract).