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急性低氧对血浆皮质醇浓度及海马去甲肾上腺素含量的影响

朱晓蔓, 高扬, 周伟君, 周予谦

(南京铁道医学院生理教研室，南京210009)

摘要

工作观察不同氧浓度(210o, 10.4%及7.90o Oz)、不同低氧时间猫血浆皮质醇浓度和海
马内去甲肾上腺素((NE)含量的改变，以分析海马在低氧应激过程中的作用。结果显示，吸入10. 4%及7. 9 Y, OZ后，猫血浆皮质醇浓度逐渐升高，分别于45 min及30 min达峰值;而低氧30 min后，海马组织中的NE含量明显降低;两者与低氧程度无明显关系。结果提示，急性低氧性应激可致血浆皮质醇浓度的升高和海马脑区NE递质含量的降低。

关键词： 低氧; 皮质醇; 去甲肾上腺素; 海马; 猫

EFFECT OF ACUTE HYPOXIA ON THE CHANGE OF HIPPOCAMPAL NE CONTENT AND PLASMA CORTISOL LEVEL

ZHU XIAO-MAN, GAO YANG, ZHOU WEI-JUN, ZHOU YU-QIAN

Department of Physiology Nanjing Railway Medical College Nanjing 210009)

Abstract

The effect of acute hypoxia on the changes of plasma cortisol level and hippocanr pus NE level of cat during inhalation of 21%，10. 4%or 7. 9%Oz were investigated.It was found that both 10. 4%and 7. 9%OZ inhalation caused a gradual increase in plasma cortisol level reaching a plateau in 30-45 min time. While the contents of NE in VHIP and DRIP showed significant decrease 30 min after hypoxia. The degree of both these changes are not related to the hypoxic level of the inhaled 02. The results show that acute hypoxic stress would induce some increase in plasma cortisol level and some decrease in hippocampus NE content.

Key words: Hypoxia;Cortisol;Norepinephrine;Hippocampus;cat

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引用本文：

朱晓蔓, 高扬, 周伟君, 周予谦. 急性低氧对血浆皮质醇浓度及海马去甲肾上腺素含量的影响[J]. 生理学报 1996; 48 (4): .

ZHU XIAO-MAN, GAO YANG, ZHOU WEI-JUN, ZHOU YU-QIAN. EFFECT OF ACUTE HYPOXIA ON THE CHANGE OF HIPPOCAMPAL NE CONTENT AND PLASMA CORTISOL LEVEL. Acta Physiol Sin 1996; 48 (4): (in Chinese with English abstract).