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大鼠延髓腹面尾端加压区与头端加压区心血管效应的差异

戴秀中潘燕霞白玉山陈斋贾秉钧

(福建医学院生理教研室，福州350009)

摘要

雄性W istar大鼠56只，乌拉坦麻醉，双侧脑区微量注射谷氨酸钠，观察延髓腹面尾端加汪区((cVMP)与头端加压区((rVMP)心血管效应的差异。结果表明:cVMP的升压效应弱于rVMP不伴随明显的心率效应，rVMP升压效应强于cVMP兼有明显的心率增加在谷氨酸钠兴奋作拜下，rVMP抑制动脉压力感受反射，而cVMP易化该反射。提示两者对心血管功能的影响具有不同的神经途径和机能意义。

关键词： 心血管效应; 动脉压力感受反射; 延髓腹外侧面; 微量注射; 谷氨酸钠

ON THE DIFFERENCE OF CARDIOVASCULAR EFFECTS BETWEEN CAUDAL VENTROLATERAL MEDULLA PRESSOR AREA (cVMP) AND ROSTROLATERAL MEDULLA PRESSOR AREA (rVMP)

DA1 XIU-ZHONG

(Deyamtrnenl of Physiology，Fujian Medical College, Fujian 350004)

Abstract

In 56 urethane anesthetized Wistar rats，bilateral microinjection of glutamate (L-
glu) was used to observe the difference of cardiovascular effects between caudal ventrolateral medulla pressor area (cVMP)and rostral ventrolateral medulla pressor area (rVMP).The results showed that the pressor effect of cVMP was weaker than that of rVMP and was not accampanied by responses in heart rate. In the latter case，an increase of heart rate was involved. The baroreflex was inhibited when rVMP was activated by L-glu but facilitated when cVMP was activated. The above results suggest that the pathway and functions of the cardiovascular effects of rVMP are differnt from those of cVMP.

Key words: cardiovascular effect;baroreflex;microinjection;glutamate;ventrolateral medulla

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引用本文：

戴秀中潘燕霞白玉山陈斋贾秉钧. 大鼠延髓腹面尾端加压区与头端加压区心血管效应的差异[J]. 生理学报 1996; 48 (4): .

DA1 XIU-ZHONG. ON THE DIFFERENCE OF CARDIOVASCULAR EFFECTS BETWEEN CAUDAL VENTROLATERAL MEDULLA PRESSOR AREA (cVMP) AND ROSTROLATERAL MEDULLA PRESSOR AREA (rVMP) . Acta Physiol Sin 1996; 48 (4): (in Chinese with English abstract).