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八肽胆囊收缩素抗内毒素休克的实验研究

凌亦凌, 黄善生, 王乐丰, 张君岚, 万梅, 郝荣利

(河北医科大学基础医学研究所，石家庄050017) ； (河北医科大学病理生理教研室，石家庄。50017)

摘要

实验观察了八肽胆囊收缩素((CCK-8)对大鼠注入内毒素(8 mg/kg b. w. iv)后血压、血液有形成分和脏器病理形态的影响，以及对醋酸铅致敏大鼠注入内毒素(1 ug/100 g b. w. iv)后24 h死亡率的影响。结果表明，CCK-8可使内毒素休克大鼠的血压明显回升((P<0. 05)，减轻血液浓缩和血小板、白细胞增多等血液有形成分的变化及L要脏器的损伤，降低24 h死亡率。上述结果提示:CCK-8确有逆转内毒素休克的作用，内毒素休克时内源性CCK-8的释放，可能具有重要的保护作用。

关键词： 胆囊收缩素; 内毒素休克; 胆囊收缩素拮抗剂; 保护作用

CHOLECYSTOKININ-OCTAPEPTIDE (CCK-8) REVERSES EXPERIMENTAL ENDOTOXIN SHOCK

ZING YI-LING , HUANG SHAN-SHENG, WANG LE-FENG, ZHANG JUN-LAN, WAN ME, HAO RONG-LI

(Institute of Basic Medical , Hebei University Shijiazhuang Department of Physiology ,Hebei Medical University Shijiazhang 050017)

Abstract

The effects of CCK一8 on the mean arterial pressure (MAP)，blood components
and path-morphological changes during endotoxin shock(endotoxin，8 mg/ kg
b. w. iv.)in rats，as well as on the 24 h mortality rate (MR)of the lead-sensitized rats in endotoxin shock一(endotoxin 1 ug/ 1'00 g b. w. iv.)were observed. The results showed that injection of CCK in ES rats led to an increase in MAP，and a reduction of hematocrit and platelet as well as white cell count;the mortality rate decreased and the lesion in main organs lessened. It is suggested that release of endogenous CCK has impor-
tant protective action during endotoxin shock.

Key words: :cholecystokinin;endotoxin shock;CCK antagonist; protective action

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引用本文：

凌亦凌, 黄善生, 王乐丰, 张君岚, 万梅, 郝荣利. 八肽胆囊收缩素抗内毒素休克的实验研究[J]. 生理学报 1996; 48 (4): .

ZING YI-LING , HUANG SHAN-SHENG, WANG LE-FENG, ZHANG JUN-LAN, WAN ME, HAO RONG-LI. CHOLECYSTOKININ-OCTAPEPTIDE (CCK-8) REVERSES EXPERIMENTAL ENDOTOXIN SHOCK. Acta Physiol Sin 1996; 48 (4): (in Chinese with English abstract).