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尾核P物质对胃运动的抑制效应系通过黑质、迷走背核经迷走神经所介导

荆浩, 张健, 林坤伟

(大连医科大学生理教研室，大连116027)

摘要

本工作观察损毁下丘脑外侧区、黑质、迷走背核及其传出神经对尾核微量注射P物质(substance P; SP)引起的胃肌电快波和胃运动抑制效应的影响。实验结果:该抑制效应不依赖于下丘脑外侧区的完整，但可被损毁黑质、迷走背核或迷走神经所消除。用利血平耗竭交感神经递质则不影响该效应。这些结果表明:尾核SP的抑胃效应系通过黑质、迷走背核经迷走神经所传出。

关键词： 尾核; P物质; 下丘脑; 黑质; 迷走背核; 迷走神经; 胃肌电活动; 胃运动

INHIBITORY EFFECT OF SUBSTANCE P OF CAUDATE NUCLEUS ON GASTRIC MOTILITY VIA SUBSTANTIA NIGRA AND DORSAL VAGAL NUCLEUS MEDIATED BY VAGUS NERVE

JING HAO, ZHANG JIAN , LIN KUN-WEI

(Department of Physiology, Dal= Medical University, Dalian 116027)

Abstract

Effects of lesion of bilateral hypothalamus (LH)，substantia nigra and dorsal vagal nucleus as well as their efferent pathway on the inhibition of gastric myoelectric fast wave and gastric motility due to injection of substance P (SP) to caudate nucleus were studied in rats. The experimental results showed that this induced inhibition was independent of the presence of intact LH but abolished by lesioning substantia nigra，dorsal vagal nucleus or vagus nerve. Depletion of sympathetic transmitter by reserpine did not affeet the occurrence of the inhibition. Thus，it appears that the gastric inhibitory effect of caudate nucleus SP is mediated via substantia nigra and dorsal vagal nucleus to vagus nerve.

Key words: Caudate nucleus; substance P;substantia nigra;dorsal vagal nucleus;gastric myoeleotric activity;gastric motility;vagus nerve ;

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引用本文：

荆浩, 张健, 林坤伟. 尾核P物质对胃运动的抑制效应系通过黑质、迷走背核经迷走神经所介导[J]. 生理学报 1996; 48 (3): .

JING HAO, ZHANG JIAN , LIN KUN-WEI. INHIBITORY EFFECT OF SUBSTANCE P OF CAUDATE NUCLEUS ON GASTRIC MOTILITY VIA SUBSTANTIA NIGRA AND DORSAL VAGAL NUCLEUS MEDIATED BY VAGUS NERVE . Acta Physiol Sin 1996; 48 (3): (in Chinese with English abstract).