过刊浏览

镁对缺血后再灌注心肌线粒体的影响

徐海, 时安云

北京医科大学病理生理教研室，北京100083)

摘要

大鼠等容心脏制备经低血流缺血((0. 2 ml/min) 60 min后复灌30 min。组(2)灌注液中镁浓度始终为1. 2 mmol/L，而组(3)及组(1)则于缺血期分别换用15 mmol/L或无镁灌注液。结果表明，高镁对心肌线粒体Caz+_ATP酶活性、合成ATP能力具明显保护作用，并减轻了钙超载现象，部分地防止缺血后再灌注损伤。

关键词： 镁; 心肌缺血; 再灌注; 钙; 线粒体

EFFECT OF MAGNESIUM ON POSTISCHEMIC REPERFUSED MYOCARDIAL MITOCHONDRIA

XU HAI, SHI AN-YUN

(Department of Pathophysiology, Beijing Medical University, Beijing 100083)

Abstract

Isovolumic rat heart preparations were exposed to low flow ischemia(0. 2 ml/min) for 60 min，followed by 30 min of reperfusion. The concentration of MgZ+ was maintained 1. 2 mmol/L throughout the study in group 2，while increased to 15 mmol/L or depleted to zero during ischemia only in group 3 and group 1 respectively. High concentration Mgz+ showed a significantly protective effect on Ca-ATPase activity and synthesis ability of ATP in myocardial mitochondria，and decreased its calcium over.load. Thus it. appears that high concentration Mgz+ infusion may partially reverse postischemic reperfusion injury to heart.

Key words: magnesium;Myocardial ischemia;Reperfusion;Calcium;mitochondria

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

徐海, 时安云. 镁对缺血后再灌注心肌线粒体的影响[J]. 生理学报 1996; 48 (3): .

XU HAI, SHI AN-YUN. EFFECT OF MAGNESIUM ON POSTISCHEMIC REPERFUSED MYOCARDIAL MITOCHONDRIA. Acta Physiol Sin 1996; 48 (3): (in Chinese with English abstract).