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降低胸膜腔内压促进冠脉血流的研究

张涛, 傅骆远, 黄作福, 牛欣

(北京心肺血管医疗研究中心动脉硬化研究室，北京100029)(北京中医药大学生理教研室，北京100029)

摘要

临床上用调控呼吸的训练方法可使冠心病患者的症状明显减轻，心功能增强，这可能是主要通过降低胸膜腔内压(以下简称胸内压)，促进了冠脉血流，改善了心肌缺血来实现的。本实验为验证此设想的真实性，对8只狗从胸膜腔反复抽气推气，造成胸内压的较大变化，以模拟深吸气动作所致的胸内压变化。结果发现:胸内压下降时，冠脉流量增大，同时发现冠脉流量的增加主要是由于右心房压明显下降，主动脉压稍有升高，而致冠脉循环的输入端和输出端压力差增大。这就为临床上调控呼吸改善心功能提供了实验依据。

关键词： 胸内压; E脉流a; 主动脉压; 右心房压; 每搏输出量; 冠脉阻力

IMPROVEMENT OF CORONARY FLOW BY ARTIFICIAL DECENDING THE INTRATHORACIC PRESSURE

ZHANG TAO, FU LONG-YUAN, HUANG ZUO-FU , NIU XIN

(Department of Arterioslerom, Beijing Heart Lung Blood!'essel Reaserch Center, Bei如ag 100029；Department of Physiology, Beijing Chinese Medicine and Pharmacology University, Beijing(Department of Physiology, Beijing Chinese Medicine and Pharmacology University, Beijing 100029)

Abstract

In simulating the changes of intrathoracic pressure during deep inhalation，the irrtrathoracic pressure was descended by repeated aspiration from thoracic cavity in 8dogs. The volume of coronary flow was observed simultaneously. It was found that when intrathoracic pressure was dropping the coronary flow volun?e showed an increase as a result of decrease of right atrium pressure and increase of aorta pressure，thus creating an increased pressure difference between inflow and outflow of coronary circulation.

Key words: intrathoracic pressure;right atrium pressure; coronary vascular resistance ;;;

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引用本文：

张涛, 傅骆远, 黄作福, 牛欣. 降低胸膜腔内压促进冠脉血流的研究[J]. 生理学报 1996; 48 (3): .

ZHANG TAO, FU LONG-YUAN, HUANG ZUO-FU , NIU XIN. IMPROVEMENT OF CORONARY FLOW BY ARTIFICIAL DECENDING THE INTRATHORACIC PRESSURE. Acta Physiol Sin 1996; 48 (3): (in Chinese with English abstract).