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刺激中缝背核对视交叉上核光敏神经元单位放电的影响

俞光第, 魏晓萍, 张惠琴, 许爽, 印其章, 邓柏澄, 钱忠明

(苏州医学院神经生物学研究室，苏州215007)(香港理工大学应用生物化学科技系)

摘要

本实验观察刺激中缝背核(DR)对大鼠视交叉上核(SCN)光敏神经元单位放电的影响，并
进行药理学分析。结果表明，刺激DR能明显抑制SCN神经元光诱发放电。这种抑制作用能被单胺氧化酶抑制剂优降宁增强，能被5-HT合成抑制剂对氯苯丙氨酸减弱，还能被5-HT受体拮抗剂赛庚睫阻断。结果提示，5-HT参与了刺激DR对SCN光敏神经元放电的抑制。

关键词： 视交叉上核; 中缝背核; 光敏神经元; 优降宁; 赛庚啶; 对氮苯丙氨酸

EFFECT OF DORSAL RAPHE NUCLEUS STIMULATION ON UNIT DISCHARGES OF LIGHT-SENSITVE NEURONS OF SUPRACHIASMATIC NUCLEUS IN RATS

YU GUANG-DI, WEI XIAO-PING, ZHANG HUI-QIN, XU SHUANG, YIN QI-ZHANG, TANG PAK-L , MAN ZHONG-MING

(Laboratory of Neurobiology, Suzhou Medical College, Suzhou 215007)

Abstract

The effect of dorsal raphe nucleus (DR)stimulation on the unit discharge of
suprachiasmatic nucleus (SCN) neurons was studied and analyzed pharmacologically in the Wistar rats. Experimental results showed that DR stimulation could significantly inhibit the light-induced discharge of SCN neurons. Pharmacologically，this inhibition could be enhanced by monoamine oxidase inhibitor pargyline，attenuated by 5-hydroxytryptamine (5-HT) synthesis inhibitor parachlorophenylalanine and blocked by 5-HTrecepor antagonist cyproheptadine. It was suggested that the inhibitory effect of DR stimulation on the light-sensitive SCN neuron discharge might be mediated by 5-HT.

Key words: Key words:suprachiasmatic nucleus; light-snsitive neuron;cypro- heptadine;;;

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引用本文：

俞光第, 魏晓萍, 张惠琴, 许爽, 印其章, 邓柏澄, 钱忠明. 刺激中缝背核对视交叉上核光敏神经元单位放电的影响[J]. 生理学报 1997; 49 (3): .

YU GUANG-DI, WEI XIAO-PING, ZHANG HUI-QIN, XU SHUANG, YIN QI-ZHANG, TANG PAK-L , MAN ZHONG-MING. EFFECT OF DORSAL RAPHE NUCLEUS STIMULATION ON UNIT DISCHARGES OF LIGHT-SENSITVE NEURONS OF SUPRACHIASMATIC NUCLEUS IN RATS . Acta Physiol Sin 1997; 49 (3): (in Chinese with English abstract).