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P物质在家兔延髓腹侧面加压区的升压作用及其机制探讨

符史干, 邓子夫, 黄承钧, 胡新武

(海南医学院生理教研室，海口570102)(同济医科大学生理教研室，武汉930030)

摘要

在乌拉坦麻醉、三碘季钱酚制动、人E呼吸的家兔上观察到，延髓腹侧面加压区(VSMP)给予P物质((SP)使血压(BP)呈剂量依赖性升高，但对心率无明显影响。VSMP给予SP受体阻
断剂使BP明显降低并可阻断SP升压效应。VSMP给予酚妥拉明或呱哇嗦预处理使SP升压效应
减弱或消失，而给予育亨宾或心得安对SP升压效应无明显影响。VSMP给予SP可使肾交感神经放电(RSND)显著增加，并伴有BP显著升高;VSMP给一予DSP使RSND和BP明显降低并可阻
断SP的RSND增加和升压效应。结果表明:SP在VSMP具有升压作用，这是由于激活VSMP的
SP受体所致，并有该局部。l受体参与介导。此升压效应主要是通过交感神经活动增强使外周血管阻力增加而实现的。VSMP的内源性SP有参与维持交感缩血管紧张性和BP水平的作用。

关键词： 关键词:P物质; P物质阻断剂; 延髓腹侧面加压区; 动脉血压; 肾交感神经放电; a:受体; 哌唑嗪

PRESSOR EFFECT OF SUBSTANCE P APPLIED TO THE PRESSOR AREA OF VENTRAL SURFACE OF MEDULLA OBLONGATA AND THE UNDERLYING MECHANISM IN RABBITS

FU SHi-GAN, DENG Zi-Fu , HUANG CHFNG-,TUN, HU XIN-WI

(Departrmeru of Physiology, Hainan Medical College Haikou 570102；Department of Tongji Medical University Wuhan Hubei 930030)

Abstract

Experiments were performed on urethane anesthetized and artificially ventilated rabbits. The results were as follows. Application of substance P (SP) to the pressor area of ventral surface of medulla oblongata (VSMp) elicited a dose-dependent increase in blood pressure (BP)，but no significant change in heart rate. The pressor response of SP was blocked by pretreatment with SP receptor antagonist (DSP) in VSMp. Application of DSP alone to VSMp elicited a significant decrease in BP. The pressor response
of SP was attenuated when VSMp was pretreated with phentolamine or prazosine，
whereas pretreatment with yohimbin or propranolol was without effect. Application of SP to VSMp elicited an increase in renal sympathetic nerve discharge (RSND) in association with pressor response;both these responses were blocked by pretreatment with DSP in VSMp. Application of DSP alone to VSMp elicited a significant decrease in RSND and BP. The above results indicate that SP has a pressor effect in VSMp due to activation of SP receptor mediated by a,一receptor. The pressor effect of SP may be mainly due to an increase of peripheral vascular resistance induced by the augmented
sympathetic nerve activity. In summary，it appears that endogenous SP in VSMp plays an important role in maintaining sympathetic tone and BP level.
Key words:substance P;substance P receptor antagonist;pressor area of ventral surface of medulla

Key words: Key words:substance P;substance P receptor antagonist;pressor area of ventral surface of medulla ;;;;

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引用本文：

符史干, 邓子夫, 黄承钧, 胡新武. P物质在家兔延髓腹侧面加压区的升压作用及其机制探讨[J]. 生理学报 1997; 49 (3): .

FU SHi-GAN, DENG Zi-Fu , HUANG CHFNG-,TUN, HU XIN-WI . PRESSOR EFFECT OF SUBSTANCE P APPLIED TO THE PRESSOR AREA OF VENTRAL SURFACE OF MEDULLA OBLONGATA AND THE UNDERLYING MECHANISM IN RABBITS. Acta Physiol Sin 1997; 49 (3): (in Chinese with English abstract).