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大鼠尾核微量注射#gamma#氨基丁酸对尾核痛反应神经元放电的影响

谷瑞民, 孙明智, 李玉荣, 张季叶, 韩为民, 刘刚

(哈尔滨医科大学生理教研室，哈尔滨150086)

摘要

在53只成年W istar大鼠上，用玻璃微电极引导神经元放电，观察了尾核内注射Y-氨基丁酸(GABA)后，尾核痛反应神经元放电的变化和印防己毒素(picrotoxin, PIC)对GABA作用的阻断效应。尾核内每2分钟分别注射GABA 25, 50, 100 ug/2 u1，尾核痛兴奋神经元(pain excitationneurons, PEN)诱发放电频率减少，潜伏期延长;痛抑制神经元(pain inhibition neurons, PIN)放电抑制时程缩短，放电频率增加。PEN和PIN电活动反应与GABA剂量间呈量效关系。尾核内注射三种剂量GABA引起的上述PEN和PIN放电变化可被每分钟腹腔注射PIC 250 ug/ml所阻断。综上表明，GABA可通过同时影响尾核PEN和PIN的电活动而产生镇痛效应。

关键词： 尾核; 神经元; #gamma#一氮基丁酸; 印防己毒素; 微量注射; 镇痛

EFFECT OF MICROINJECTION OF GABA INTO THE CAUDADE NUCLEUS ON ELECTRICAL DISCHARGES OF NOCICEPTIVE NEURONS IN CAUDATE NUCLEUS OF RAT

GU Rui min, SUN Min-zhi, Li Yu-rong, ZHANG JI_YE, HAN WEI-MIN, LIU GANG

(Department of Physiology, Harbin Medical University, Harbin 150086)

Abstract

The characteristics of glass microelectrode recorded electrical activity of nociceptive neurons in the caudate nucleus elicited by microinjection of GABA and blockage by picrotoxin (PIC) were studied in 53 Wistar rats. The results showed that GABA (25，50，]00 4g/2 41 every 2 min) inhibited the activity of pain excitation neurons (PEN)，as shown by decreased frequency and increased latency，but enhanced the activity of pian inhibition neurons (PIN)，as shown by shortened duration and increased discharge frequency. Both activities are highly dose-dependent and could be blocked by PIC (ip
250 }ig，1 ml/1 min).

Key words: caudate nucleus;neuron;;;;

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引用本文：

谷瑞民, 孙明智, 李玉荣, 张季叶, 韩为民, 刘刚. 大鼠尾核微量注射#gamma#氨基丁酸对尾核痛反应神经元放电的影响[J]. 生理学报 1997; 49 (2): .

GU Rui min, SUN Min-zhi, Li Yu-rong, ZHANG JI_YE, HAN WEI-MIN, LIU GANG. EFFECT OF MICROINJECTION OF GABA INTO THE CAUDADE NUCLEUS ON ELECTRICAL DISCHARGES OF NOCICEPTIVE NEURONS IN CAUDATE NUCLEUS OF RAT. Acta Physiol Sin 1997; 49 (2): (in Chinese with English abstract).