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刺激中缝背核对大鼠小脑皮层下核团神经元电活动的影响

陈文雁, 王建军, 余启祥

(南京大学生物科学与技术系生理教研室，南京210093)

摘要

我们首次观察了电刺激大鼠中缝背核(DR)对小脑核团(DCN)—内侧核(MN)，间位
核(IN)和外侧核(LN)神经元电活动的影响。结果表明:刺激DR可引起DCN神经元的抑制、
兴奋和双相(兴奋一抑制、抑制一兴奋)三种不同类型的反应，其中以抑制性反应为主(76%一BO0o);反应的潜伏期为10-84 ms，但大多数细胞呈现小于30 ms的短潜伏期反应;DCN细胞
的自发放电频率为5-120 Hz，自发放电频率高的神经元群体对DR刺激的反应比率却比自发放电频率低的群体低;静脉注射5-HT,/,。受体阻断剂methysergide可以阻断DCN细胞对DR刺激的抑制性反应(66.700-83.300)。这些结果提示中缝一小脑5-HT能纤维传入系统可能通过对DCN细胞电活动的调制作用参予小脑的感觉运动整合过程。
关键词:中缝背核;小脑深部核团;中缝一小脑投射;5-HT能纤维

关键词： 中缝背核; 小脑深部核团; 中缝一小脑投射; 5-HT能纤维

EFFECTS OF DORSAL RAPHE STIMULATION ON ACTIVITIES OF CEREBELLAR NUCLEAR NEURONS IN THE RAT

CHEN WEN-YAN , WANG Jian-Jun, YU QI-XIANG

(Division of Physiology, Department of Biological Science and Tedmology, Nanjing University, Nanjing 210093)

Abstract

The effects of stimulating dorsal raphe nucleus (DR)on activities of three deep cerebellar nuclei (DCN) (medial，interposed and lateral nuclei) were investigated. The results were as follows:(1)Stimulation of DR elicited three types of responses，inhibition，excitation，and biphasic response (excitation-inhibition or inhibition-excitation)from DCN cells with responsive latencies ranging from 10 to 84 ms. The majority of responsive cells showed an inhibitory response (76%一90肠)with a latency less than 30 ms. (2) The spontaneous discharge frequencies of the DCN cells were 5 to 120 Hz.
The cells with higher spontaneous discharge frequencies showed low responsive rates to the DR stimulation，as compared with lower firing frequency cells. (3) The depressive effect of DR stimulation could be blocked by injection of 5-HTZ/I,, antagonist meth sergide (66. 7%一83. 3%).These results suggest that raphe-cerebellum serotonergic afferent fibers may be involved in the cerebellar sensorimotor integration process by exerting some modulatory effects on the DCN cell' s activities.

Key words: dorsal raphe nucleus;deep cerebellar nucleus; raphe-cerebellar projection; serotonergic fibers

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引用本文：

陈文雁, 王建军, 余启祥. 刺激中缝背核对大鼠小脑皮层下核团神经元电活动的影响[J]. 生理学报 1996; 48 (2): .

CHEN WEN-YAN , WANG Jian-Jun, YU QI-XIANG. EFFECTS OF DORSAL RAPHE STIMULATION ON ACTIVITIES OF CEREBELLAR NUCLEAR NEURONS IN THE RAT. Acta Physiol Sin 1996; 48 (2): (in Chinese with English abstract).