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心脏肾素一血管紧张素系统在游泳引起的生理性心肌肥大中的作用

田斌, 高广道, 刘健, 曹治平, 卢兴

(西安医科大学病理生理教研室，西安710061)；北京医科大学第三临床医学院血管医学研究所，北京100083)

摘要

实验采用游泳训练((SW)引起的大鼠心肌肥大模型，通过放射免疫及生化等方法，对生理性心肌肥大时，心脏和循环肾素一血管紧张素系统(RAS)的变化进行了初步研究。观察八泳五周时，大鼠左、右心室重与体重比值(V/Bwt)显著升高，同时，左、右室心肌血管紧张素I (Ang I)“含量及心肌Ang转换酶(ACE)活性也较对照组明显升高((P<0. 05)。心肌Ang IV/Bwt之间存在明显的正相关关系(-r=0.7721, P

关键词： 心肌肥大; 血管紧张素I; 肾素

ROLE OF CARDIAC RENIN-ANGIOTENSIN SYSTEM IN SWIMMING INDUCED PHYSIOLOGICAL MYOCARDIAL HYPERTROPHY

Tian Bin, Gao Guangdao, Liujian, Cao Zhiping, Luxing

(Department of Pathophysudogy, Xian Medical University, Xian 71006’Institute of Vascular Medicine, The Third School of Clinical Medicine, Beijing Medical University, Beijing 100081)

Abstract

To determine the contribution of cardiac renin-angiotensin system (RAS) to the physiological myocardial hypertrophy induced by swimming training and the relationship between locally produced and circulating RAS，both ventricular and plasma angiotensin(Ang)I and I contents，ventricular angiotensin converting enzyme (ACE) and plasma renin activity (PRA) were detected by means of radioimmunoassay and biochemical method. It was shown that after 5 weeks of swimming，the ventricular wet weight to body weight ratio (V /Bwt) and Ang I in both left and right ventricles and ACE activity increased markedly as compared with the controls (PLO. 05). Furthermore，significantly possitive correlation was found between the ventricular Ang I and V /Bwt(:=0. 7721，PGO. 001)，while the plasma Ang I and I and PRA remained at the control level. No correlation was found between plasma Ang I and V /
Bwt. These above findings suggest that cardiac RAS may play an important role in physiological myocardial hypertrophy and to a large extent is in dependent on circulating RAS.

Key words: myocardial hypertrohy;angiotnesin lI;renin

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引用本文：

田斌, 高广道, 刘健, 曹治平, 卢兴. 心脏肾素一血管紧张素系统在游泳引起的生理性心肌肥大中的作用[J]. 生理学报 1994; 46 (5): .

Tian Bin, Gao Guangdao, Liujian, Cao Zhiping, Luxing. ROLE OF CARDIAC RENIN-ANGIOTENSIN SYSTEM IN SWIMMING INDUCED PHYSIOLOGICAL MYOCARDIAL HYPERTROPHY. Acta Physiol Sin 1994; 46 (5): (in Chinese with English abstract).