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四氢小檗碱的中枢抑制作用与GABA受体无关

汪晓立, 金国章, 周廷冲

中国科学院上海药物研究所 上海 200031；军事医学科学院基础医学研究所 北京 100850

摘要

应用蚯蚓背肌收缩反应，证实四氢小巢碱(THB, 10-7-10-"mol/L)不能影响GABA和ACh
两种受体的功能，多巴胺受体阻滞剂氟呱啶醇(HAL)亦不能影响它们。由于异烟阱(INH)和
氨基硫脉(TSC)抑制GABA的生物合成，印防己毒素(PT)和毕枯枯灵(Bic)作用于GABA-
BZ受体复合体，它们都使小鼠产生惊厥，该作用能被氨基氧乙酸(AOAA)和安定(BZ)所拮
抗，但THB和HAL却不能。由此表明前述THB的中枢抑制作用与GABA抑制无关。

关键词： 四氢小檗碱; 蚯蚓背肌; 惊厥; #gama#-氨基丁酸; 多巴胺

ON THE CENTRAL INHIBITION ACTION OF TETRAHYDROBERBERINE WITHOUT RELEVANCE TO GABA RECEPTORS

Wang Xiaoli, Jing Guozhang, Zhou Tingchong

Shanghai Institute of Materia Medical Academy of Science 200031；Institute of Basic Medical Science Academy of Military Science Beijing 100850

Abstract

Using an earthworm (Eisenia foetida) dorsal muscle preparatioO}，it was shown that tetrahydroberberine (THB，10~(7)一10~(4) mol/L) did not affect both GABA and ACh receptors. DA receptor antagonist haloperidol (HAL) also exerted no effect. Owing to the blocking action of isonicotinyl hydrazine(INH)and thiosemicarbazide (TSC) on biosynthesis of GABA，and of picrotoxin (PT) and bicuculline (Bic) on the GABA-BZ receptor complex mediated transmission，all these agents could induce convulsion in mice. This action could be antagonized by amino- oxyacetic acid (AOAA)and benzodiazepine (8Z)，but not by DA receptor antagonists THB and HAL. All the above observations indicate that the GABA inhibition is not involved in the central action of THB.

Key words: tetrahydroberberine;earthworm dorsal muscle;;;

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引用本文：

汪晓立, 金国章, 周廷冲. 四氢小檗碱的中枢抑制作用与GABA受体无关[J]. 生理学报 1994; 46 (5): .

Wang Xiaoli, Jing Guozhang, Zhou Tingchong. ON THE CENTRAL INHIBITION ACTION OF TETRAHYDROBERBERINE WITHOUT RELEVANCE TO GABA RECEPTORS . Acta Physiol Sin 1994; 46 (5): (in Chinese with English abstract).