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川芎嗪加强豚鼠乳头状肌慢内向电流的作用

白琴, 汤树木

(河南医科大学生理教研室，郑州450052)

摘要

川芎嗪剂量依赖性地增加正常豚鼠乳头状肌收缩力((FC)，延长快反应动作电位时程
(APD)。川芎嗪使氯化钡或组织胺诱发的慢反应电位(SAP)的动作电位幅值((APA), APD,最
大除极速率(Vmex)及FC呈剂量依赖性增加。3. 0 mmol/L的川芎嗪可直接诱发高钾除极化，钠通道失活的豚鼠乳头状肌的SAP和收缩，加入1 umol/L维拉帕米后10 min内，SAP及收缩逐步消失。但川芍嚓不能在儿茶酚胺耗竭或普蔡洛尔阻断日受体的乳头状肌上诱发SAP及收缩。以上结果提示川芎嗪加强慢内向电流的作用可能是通过心肌内儿茶酚胺释放所介导的。

关键词： 川芎嗪; 乳头状肌; 动作电位; 心肌收缩力; 钙内流

ENHANCEMENT EFFECT OF TETRAMETHYLPYRAZINE ON SLOW INWARD CURRENT IN GUINEA PIG PAPILLARY MUSCLES

Bai Qin, Tang Shumu

Department of Physiology,Henan Medical University Zhenzhou 450052

Abstract

Tetramethylpyrazine (TMP) could potentiate the force of contraction and increase the action potential duration (APD) of isolated guinea pig papillary muscles in a dosedependent manner. Similar effects were also observable in BaCl2 or histamine-induced contraction and the accompanied slow action potential (SAP). In fact，contraction and SAP could also be induced by TMP itself at 3. 0 mmol/L concentration and antagonized by verapamil(1 }tmol/L) within 10 min. In the presence of propranolol or in experiments carried out in.catecholamine-depleted (reserpine 2. 5 mg/kg，i. p. 15 h prior to
the experiment) muscles，TMP was unable to induce SAP and contraction. These results suggested that the effects of TMP on enhancing Is; were mediated by the release of catecholamine in myocardium.

Key words: :tetramethylpyrazine;Papillary muscles; action potential;myocardial contraction; calcium influx

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引用本文：

白琴, 汤树木. 川芎嗪加强豚鼠乳头状肌慢内向电流的作用[J]. 生理学报 1994; 46 (5): .

Bai Qin, Tang Shumu. ENHANCEMENT EFFECT OF TETRAMETHYLPYRAZINE ON SLOW INWARD CURRENT IN GUINEA PIG PAPILLARY MUSCLES. Acta Physiol Sin 1994; 46 (5): (in Chinese with English abstract).