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豚鼠主动脉前庭组织的自律性研究和形态学观察

陈彦静, 葛赋贵

张家口医学院生理教研室 张家口 075029

摘要

用细胞内微电极技术，对82只豚鼠主动脉前庭的自发电活动进行了观察和分析。结果表明，16例(19.50o)出现自律性电活动;61例(79. 9%)在电刺激诱导下也可出现自律性电活
动。进一步观察发现，在主动脉瓣右瓣与后瓣交界以下的局部区域，可记录到有明显9相自动去极化的慢反应自律细胞样的动作电位，并可被钙通道阻滞剂Mn'十、硝苯毗睫阻断。这一部位之外的其它大部分区域均表现为快反应动作电位。经光镜和电镜观察((n=13)，这一部位的组织与普通心室肌有明显不同，而与慢反应自律组织的结构相似。

关键词： 主动脉前庭; 自律性; 慢反应电位; Mn Z+ ; 硝苯毗咤; 形态学

A STUDY OF AUTOMATIC ACTIVITY AND MORPHOLOGY OF GUINEA-PIG AORTIC VESTIBULE

Cheng Zhiping

Department of Physiology harbin Medical University , harbin 150086

Abstract

The automatic activity of aortic vestibule was studied in 82 guinea-pig heart preparations with intracellular microelectrode. Spontaneous activity could be recorded in 16 preparations(19.5%)，while in 61 preparations (74. 4%)automatic activity could be induced by electrical stimulation. Of these preparations，they were all found a very small region below the right and the poster valves，the response showed a slow and low rising phase and a marked spontaneous depolarization in phase 4. The response could be blocked by Mnz+ and nifedipine. Outside of the specialized valve region，all recorded
vestibule action potentials pertain to the fast type. Light and electron microscopic examination showed that the structure of the specialized local aortic vestibule region was similar to that of ordinary myocardium possessing slow automatic activity instaed of the ordinary ventricular musculature.

Key words: aortic vestibule;sutomaticity;;;nifedipine;morphology

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引用本文：

陈彦静, 葛赋贵. 豚鼠主动脉前庭组织的自律性研究和形态学观察[J]. 生理学报 1994; 46 (5): .

Cheng Zhiping. A STUDY OF AUTOMATIC ACTIVITY AND MORPHOLOGY OF GUINEA-PIG AORTIC VESTIBULE . Acta Physiol Sin 1994; 46 (5): (in Chinese with English abstract).