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乙酰唑胺对氧惊厥潜伏期的影响

黄俊龙, 马彦雯, 练庆林, 徐建平, 蒋春雷, 郭明珠, 孙学军

第二军医大学海军医学系航海医学教研室.上海 200433

摘要

为探讨脑血流调节与氧惊厥的关系,在复制大鼠氧惊厥模型的基础上,采用行为学方法测定氧惊厥潜伏期,并测定不同部位脑组织氧化与抗氧化指标,采用腹腔注射不同剂量脑血管扩张药物乙酰唑胺,观察脑血管扩张对氧化状态以及氧惊厥潜伏期的影响。观察结果为:(1)与生理盐水组相比,乙酰唑胺200、20mg/kg体重组腹腔给药后氧惊厥潜伏期(纯氧6 ATA暴露)明显缩短(P<0.01),乙酰唑胺2mg/kg体重组无明显改变(P>0.05);(2)腹腔给乙酰唑胺(20mg/kg体重)或生理盐水后,各组各部位脑组织GSH-PX无显著差异(P>0.05);但随暴露时间的延长,其活力呈现先升高后降低的趋势;与对照组相比,乙酰唑胺6min组和生理盐水16min组皮层丙二醛(MDA)含量均明显增多(P<0.01),乙酰唑胺16min组海马MDA含量明显增多(P<0.01)。结果表明,乙酰唑胺可缩短氧惊厥潜伏期,加重脑组织氧化损伤。

Effect of acetazolamide on the latency of hyperbaric oxygen-induced convulsion

Huang Junlong, Ma Yanwen, Lian Qinglin, Xu Jianping, Jiang Chunlei, Guo Mingzhu, Sun Xuejun

Department of Nautical Medicine,Faculty of Naval Medicine,Second Military Medical University.Shanghai 200433

Abstract

These results suggest hat acetazolamide which dilates the brain arteriolar obviously shortens the latency of hyperbaric oxygen-induced convulsion, and that acetazolamide dilates the vessels and increases the supply of the oxygen breaking into the brain tissues and aggravates the oxidation. The hyperbaric oxygen-induced convulsion correlates closely with the oxidation injury.

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引用本文：

黄俊龙, 马彦雯, 练庆林, 徐建平, 蒋春雷, 郭明珠, 孙学军. 乙酰唑胺对氧惊厥潜伏期的影响[J]. 生理学报 2004; 56 (2): .

Huang Junlong, Ma Yanwen, Lian Qinglin, Xu Jianping, Jiang Chunlei, Guo Mingzhu, Sun Xuejun. Effect of acetazolamide on the latency of hyperbaric oxygen-induced convulsion. Acta Physiol Sin 2004; 56 (2): (in Chinese with English abstract).