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采用共聚焦显微术对家兔呼吸道感受器进行观察

王玉芳, 於峻

路易维尔大学内科系与生理系.美国,肯塔基州 40292

摘要

各级气道均有多种不同的感受器结构。大气道中的结构往往比小气道中的复杂,虽然它们的大小、所在部位与走向不尽相同,但都有多个终端末梢。有些感受器埋置在气道平滑肌中,其结构便地感受对气道的机械性刺激;有些覆盖在气道上皮的表面,其形态适合于感受通过气道的刺激性物质;另一些则位于气道粘膜下,在上皮与平滑肌之间。有些传入神经轴突可支配多个感受器结构。据此,传入单纤维中记录到的电活动是来自一个感觉电位。后者可以由多个感受器组成。除了感受器之外,还观察到气道内神经节,它们与感受神经的轴突密切相关。该文证实气道内存在不同形态结构的感受器,并探讨了其生理分类。

Structural survey of airway sensory receptors in the rabbit using confocal microscopy

Wang Yufang, Yu J

Department of Medicine,and Physiology and Biophysics,University of Louisville,Louisville,KY 40292

Abstract

Information on the morphology of airway receptors is limited. The present study surveys rabbit airway receptors using immunohistochemical and fluorescent labeling to identify their structure with confocal microscopy. Various receptor types were observed to have multiple branches where a parent axon fed several structures. Receptors were located in different layers of the airway, i.e., smooth muscle, lamina propria (submucosa) and the epithelium. Smooth muscle and submucosal receptors were innervated by thick myelinated fibers, while epithelial receptors were supplied by thin-diameter axons. Structures of smooth muscle receptors and some submucosal receptors covered a relatively large area,while epithelial receptors were less extended. In addition, intrapulmonary ganglia were also labeled. Some were closely associated with the axons of smooth muscle receptors.

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引用本文：

王玉芳, 於峻. 采用共聚焦显微术对家兔呼吸道感受器进行观察[J]. 生理学报 2004; 56 (2): .

Wang Yufang, Yu J. Structural survey of airway sensory receptors in the rabbit using confocal microscopy. Acta Physiol Sin 2004; 56 (2): (in Chinese with English abstract).