过刊浏览

一氧化氮对过氧化氢所致听力损失的保护作用

赖丹, 黎万荣, 李兴启

泸州医学院附属医院耳鼻咽喉-头颈外科.四川,泸州 646000；解放军耳鼻咽喉科研究所.北京 100853

摘要

灌流H_(2)O_(2+L-精氨酸组的CAP阈移和CM下降幅度值明显低于单独灌流H_(2)O_(2)组,差异有显著性(P<0.05);前者形态学观察未见明显的细胞损伤,后者可见大量坏死红染的细胞。H_(2)O_(2)+L-精氨酸+L-NNA组CAP阈移和CM下降幅度与单独灌流H_(2)O_(2)组比较无统计学差异。实验结果提示NO可能通过NO/cGMP途径部分对抗过氧化氢所致的听力损失。

Protective effect of nitric oxide against hydrogen peroxide-induced hearing loss

Lai Dan, Li Wanrong, Li Xingqi

Department of Otorhinolaryngology Head and Neck Surgery,First Hospital of Luzhou Medical College.Luzhou 646000,Sichuan；China

Abstract

Previous research showed that reactive oxygen species (ROS) play an important role in ototoxicity. Our results suggest that nitric oxide may partly be able to protect guinea pigs from hydrogen peroxide-induced hearing loss.

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

赖丹, 黎万荣, 李兴启. 一氧化氮对过氧化氢所致听力损失的保护作用[J]. 生理学报 2004; 56 (2): .

Lai Dan, Li Wanrong, Li Xingqi. Protective effect of nitric oxide against hydrogen peroxide-induced hearing loss. Acta Physiol Sin 2004; 56 (2): (in Chinese with English abstract).