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大鼠侧脑室内注射组胺对颈动脉窦压力感受性反射的影响及其中枢机制

王国卿, 周希平, 黄伟秋

苏州大学医学院基础医学系生理学教研室.江苏,苏州 215007

摘要

侧脑室给HA使CSR产生快速重调定,反射敏感性下降,功能受抑;其机制是通过中枢HA受体介导,H_(1)受体的作用比H_(2)受体更为明显;下丘脑-NTS的HA能通路可能是HA调节CSR的下行通路之一,NTS处的HA受体在i.c.v. HA抑制CSR的机制中可能发挥重要的作用。

关键词： 颈动脉窦压力感受性反射; 组胺; 氯苯吡胺; 西咪替丁; 侧脑室注射; 孤束核; 平均动脉压

Effect of intracerebroventricular injection of histamine on carotid sinus baroreceptor reflex in anesthetized rats and its mechanism

Wang Guoqing, Zhou Xiping, Huang Weiqiu

Department of Physiology,Medical School,Soochow University.Suzhou 215007,Jiangsu

Abstract

The main results obtained are as follows. (1) i.c.v. injection of HA (100 ng) significantly shifted the ISP-MAP relationship curve upwards and moved the middle part ofo ISP-Gain relationship curve downwards, and reduced the MAP range and maximum gain (G_(max)), but increased the threshold pressure (TP), saturation pressure (SP) and ISP at G_(max) (ISP_(Gmax)). (2) The pretreatment with H_(1) or H_(2) receptors antagonist, chlorpheniramine (CHL, 5#mu#g) or cimetidine (CIM, 15#mu#g), could obviously diminish the above-mentioned changes in CSR performance induced by HA, but the effect of CIM was less remarkable than that of CHL. (3) The pretreatment with both CHL and CIM (5 #mu#g and 15 #mu#g) at the same time abolished the responses of CSR performance to HA completely. (4) After microinjection of CHL (0.5 #mu#g) or CIM (1.5 #mu#g) into the NTS, the responses of CSR to HA were similar to those after i. c. v. CHL or CIM, but the change in TP was significantly decreased.

Key words: Carotid sinus baroreceptor reflex;Histamine;Chlorpheniramine;Cimetidine;Intracerebreventricular injection;Nucleus of solitary tract;Mean arterial pressure

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引用本文：

王国卿, 周希平, 黄伟秋. 大鼠侧脑室内注射组胺对颈动脉窦压力感受性反射的影响及其中枢机制[J]. 生理学报 2002; 54 (6): .

Wang Guoqing, Zhou Xiping, Huang Weiqiu. Effect of intracerebroventricular injection of histamine on carotid sinus baroreceptor reflex in anesthetized rats and its mechanism. Acta Physiol Sin 2002; 54 (6): (in Chinese with English abstract).