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肺内调节肽对兔支气管上皮细胞分泌白介素的影响

谭宇蓉, 秦晓群, 管茶香, 张长青, 向阳, 任雁宏

中南大学湘雅医学院生理学教研室.湖南,长沙 410078

摘要

血管活性肠肽(vasoactive intestinal peptide, VIP)对未受应激BECs存在抑制作用,并使臭氧应激BECs分泌ILs下降;表皮生长因子(epidermal growth factor,EGF)使未受应激BECs IL-1、IL-8分泌增加,使臭氧应激的BECs ILs分泌降低;内皮素-1(endothelin-1,ET-1)、降钙素基因相关肽(calcitonin gene-related peptide,CGRP)可使未受应激的BECs分泌ILs增加,CGRP还可使臭氧应激的BECs ILs分泌增加。

关键词： 肺内调节肽; 支气管上皮细胞; 白细胞介素

Influence of regulatory peptides on the secretion of interleukins from bronchial epithelial cells of the rabbit

Tan Yurong, Qin Xiaoqun, Guan Chaxiang, Zhang Changqing, Xiang Yang, Ren Yanhong

Department of Physiology,Xiangya Medical College,Central South University.Changsha 410078,Hunan

Abstract

The results of the experiments showed that VIP exerted an inhibitory effect on the secretion of IL-1 and IL-8 from unstimulated and O_(3)-stressed BECs, VIP also decreased the secretion of IL-5 from O_(3)-stressed BECs; EGF promoted secretion of IL-1 and IL-8 from unstimulated BECs, but decreased the secretion of ILs from O_(3)-stressed BECs; ET-1 and CGRP enhanced the secretion of IL-1, IL-5, and IL-8 from unstimlated BECs, CGRP also increased the secretion of ILs from O_(3)-stressed BECs.

Key words: Regulatory peptides;Secretion;Bronchial epithelial cells

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引用本文：

谭宇蓉, 秦晓群, 管茶香, 张长青, 向阳, 任雁宏. 肺内调节肽对兔支气管上皮细胞分泌白介素的影响[J]. 生理学报 2002; 54 (2): .

Tan Yurong, Qin Xiaoqun, Guan Chaxiang, Zhang Changqing, Xiang Yang, Ren Yanhong. Influence of regulatory peptides on the secretion of interleukins from bronchial epithelial cells of the rabbit. Acta Physiol Sin 2002; 54 (2): (in Chinese with English abstract).