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血小板源生长因子受体介导的信号转导在自发性高血压大鼠心肌肥大中的作用

刘洁, 白桦, 邢东琦, 孙银平, 吴立玲

北京大学医学部生理与病理生理学系.北京 100083；邮电总医院心内科.北京 100032；新乡医学院病理生理学教研室.河南,新乡 453003

摘要

为了探索血小板源生长因子(platelet-derived growth factor,PDGF)受体介导的信号转导在自发性高血压大鼠(spontaneously hypertensive rats,SHR)心肌肥大中的作用,实验采用Western blot法检测SHR及其对照WKY大鼠心肌PDGF受体#beta#和细胞外信号调节激酶(extracellular signal-regulated kinase 1/2,ERK 1/2)的蛋白表达和ERK 1/2磷酸化水平的变化。

关键词： 血小板源生长因子受体; 信号转导; 心肌肥大; 自发性高血压大鼠

Role of platelet-derived growth factor receptor-mediated signal transduction in myocardial hypertrophy of spontaneously hypertensive rats

Liu Jie, Bai Hua, Xing Dongqi, Sun Yinping, Wu Liling

Department of Physiology and Pathophysiology,Peking University Health Science Center.Beijing 100083；China；Department of Pathophysiology,Xinxiang Medical College.Xinxiang 453003,Henan

Abstract

The role of platelet-derived growth factor (PDGF) receptor-mediated signal transduction in myocardial hypertrophy of spontaneously hypertensive rats (SHR) was investigated. The protein expressions of PDGF #beta# receptor and extracellular signal-regulated kinase 1/2 (ERK 1/2) and the level of phosphorylated ERK 1/2 (pERK 1/2) in cardiac tissues from 4- and 12-week-old SHR and their age-matched normotensive control Wistar-Kyoto rats (WKY) were examined by Western blot analysis.

Key words: Platelet-derived growth factor receptor;Signal transduction;Myocardial hypertrophy;Spontaneously hypertensive rats

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引用本文：

刘洁, 白桦, 邢东琦, 孙银平, 吴立玲. 血小板源生长因子受体介导的信号转导在自发性高血压大鼠心肌肥大中的作用[J]. 生理学报 2002; 54 (2): .

Liu Jie, Bai Hua, Xing Dongqi, Sun Yinping, Wu Liling. Role of platelet-derived growth factor receptor-mediated signal transduction in myocardial hypertrophy of spontaneously hypertensive rats. Acta Physiol Sin 2002; 54 (2): (in Chinese with English abstract).