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血管活性肠肽对支气管上皮细胞趋化迁移的影响及机制

管茶香, 张长青, 秦晓群, 罗自强, 周伏文, 孙秀泓

中南大学湘雅医学院生理学教研室.湖南,长沙 410078

摘要

肺内神经肽VIP可增强BEC的趋化迁移,其细胞内信号转导途径与钙调蛋白及蛋白激酶C有关。而热应激时VIP及VIPR的高表达进一步提示局部微环境的VIP可能是气道上皮损伤修复网络中的重要分子。

关键词： 血管活性肠肽; 支气管上皮细胞; 趋化性; 血管活性肠肽受体

Effects of vasoactive intestinal peptide on chemotaxis of bronchial epithelial cells

Guan Chaxiang, Zhang Changqing, Qin Xiaoqun, Luo Ziqiang, Zhou Fuwen, Sun Xiuhong

Department of Physiology,Xiangya Medical College,Central South University.Changsha 410078,Hunan

Abstract

These results indicate that VIP in the lungs may play an important role in the repair of damaged epithelium, accelerating restoration of the airway to its normal state. Calmodulin and protein kinase C may be involved in the signal transduction of VIP effects.

Key words: Vasoactive intestinal peptide;bronchial epithelial cells;Chemotaxis;Vasoactive intestinal peptide receptor

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引用本文：

管茶香, 张长青, 秦晓群, 罗自强, 周伏文, 孙秀泓. 血管活性肠肽对支气管上皮细胞趋化迁移的影响及机制[J]. 生理学报 2002; 54 (2): .

Guan Chaxiang, Zhang Changqing, Qin Xiaoqun, Luo Ziqiang, Zhou Fuwen, Sun Xiuhong. Effects of vasoactive intestinal peptide on chemotaxis of bronchial epithelial cells. Acta Physiol Sin 2002; 54 (2): (in Chinese with English abstract).