过刊浏览

肺内调节肽对兔支气管上皮细胞与嗜酸性粒细胞粘附功能的影响及机制探讨

谭宇蓉, 秦晓群, 管茶香, 张长青

中南大学湘雅医学院生理学教研室.湖南,长沙 410078

摘要

观察了血管活性肠肽(vasoactive intestinal peptide,VIP)、表皮生长因子(epidermal growth factor,EGF)、内皮素-1(endothelin-1,ET-1)、降钙素基因相关肽(calcitonin gene-related peptide,CGRP)在未受应激与臭氧应激两种条件下对支气管上皮细胞(bronchial epithelial cell, BEC)与嗜酸性粒细胞(eosinophil,EOS)粘附的影响。提示介导BEC与EOS粘附的粘附分子可能是ICAM-1。

关键词： 肺内调节肽; 支气管上皮细胞; 嗜酸性粒细胞

Effects of regulatory peptides on adhesion of eosinophil to bronchial epithelial cells

Tan Yurong, Qin Xiaoqun, Guan Chaxiang, Zhang Changqing

Department of Physiology,Xiang Ya Medical College,Central South University.Changsha 410078,Hunan

Abstract

To explore the roles of regulatory peptides in the process of various anaphylactic inflammation of the airway, we observed the influence of four peptides, i.e., vasoactive intestinal peptide (VIP), epidermal growth factor (EGF), endothelin-1 (ET-1), and calcitonin gene-related peptide (CGRP), on the adhesion of eosinophil (EOS) to unstimulated and O_(3)-stressed bronchial epithlial cells (BEC).

Key words: Regulatory peptides;Eosinophil;Bronchial epithelial cells

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

谭宇蓉, 秦晓群, 管茶香, 张长青. 肺内调节肽对兔支气管上皮细胞与嗜酸性粒细胞粘附功能的影响及机制探讨[J]. 生理学报 2002; 54 (1): .

Tan Yurong, Qin Xiaoqun, Guan Chaxiang, Zhang Changqing. Effects of regulatory peptides on adhesion of eosinophil to bronchial epithelial cells. Acta Physiol Sin 2002; 54 (1): (in Chinese with English abstract).