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肾缺血引起大鼠儿茶酚胺神经元Fos表达

丁延峰, 张小雪, 王义和, 石葛明, 何瑞荣

河北医科大学基础医学研究所生理室.河北,石家庄 050017；河北医科大学解剖教研室.河北,石家庄 050017；武警医学院生理教研室.天津 300162

摘要

实验应用Fos蛋白和酪氨酸羧化酶(tyrosine hydroxylase,TH)的双重免疫组化方法,观察肾脏动脉阻断(renal artery occulusion,RAO)是否激活脑干中核团的儿茶酚胺能神经元。结果表明,肾脏短暂缺血能激活脑干内的一些神经核团以及其中的部分儿茶酚胺能神经元。此效应可能是肾缺血时腺苷释放作用于肾内腺苷受体后引起肾传入神经活动增加的结果。

关键词： 肾缺血; 脑干; Fos免疫组织化学反应; 酪氨酸羟化酶; 腺苷; 8-苯茶碱

Renal ischemia-induced Fos expression in catecholaminergic neurons of rats

Ding Yanfeng, Zhang Xiaoxue, Wang Yihe, Shi Geming, He Ruirong

Departments of Physiology,Hebei Medical University.Shijiazhuang 050017,Hebei；China；Department of Physiology,Wujing Medical College.Tianjin 300162

Abstract

The results suggest that RAO can activate a large number of neurons including some catecholaminergic neurons in the brainstem nuclei. Such effects of renal ischemia may be attributed to RAO-induced adenosine release from the kidney which subsequently activates renal afferents.

Key words: renal ischemia;Brainstem;Fos immunohistochemistry;Tyrosine hydroxylase;Adenosine;8-phenyltheophylline

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引用本文：

丁延峰, 张小雪, 王义和, 石葛明, 何瑞荣. 肾缺血引起大鼠儿茶酚胺神经元Fos表达[J]. 生理学报 2001; 53 (6): .

Ding Yanfeng, Zhang Xiaoxue, Wang Yihe, Shi Geming, He Ruirong. Renal ischemia-induced Fos expression in catecholaminergic neurons of rats. Acta Physiol Sin 2001; 53 (6): (in Chinese with English abstract).