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肾上腺髓质素对大鼠损伤性心肌肌浆网功能的改善

李贤峰, 杨晔, 高连茹, 齐永芬, 李载权, 唐朝枢

海军总医院心内科.北京 100037；北京大学第一医院心血管病研究所.北京 100034

摘要

Adm对ISO诱导的大鼠心肌损伤具有保护作用,其机制可能与Adm增加SR Ca~(2+)-ATPase活性、增加~(3)H-ryanodine所致SR Ca~(2+)摄取和释放升高有关。外源性给予Adm对损伤心肌可能具有临床治疗作用。

关键词： 肾上腺髓质素; 肌浆网; 钙离子摄取; 钙离子释放; 3H-ryanodine

Ameliorative effects of adrenomedullin on rat cardiac sarcoplasmic reticulum injured by isoproterenol

Li Xianfeng, Yang Ye, Gao Lianru, Qi Yongfen, Li Zaiquan, Tang Chaoshu

Department of Cardiology,Navy General Hospital.Beijing 100037；China

Abstract

It seems that Adm exerted a protective effect on cardiac function in injured rat heart by enhancing SR Ca~(2+) uptake and release, suggesting that Adm may play a therapeutic role in myocardial injury.

Key words: Adrenomedullin;Sarcoplasmic reticulum;Ca~(2+) uptake;Ca~(2+) release;~(3)H ryanodine

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引用本文：

李贤峰, 杨晔, 高连茹, 齐永芬, 李载权, 唐朝枢. 肾上腺髓质素对大鼠损伤性心肌肌浆网功能的改善[J]. 生理学报 2001; 53 (5): .

Li Xianfeng, Yang Ye, Gao Lianru, Qi Yongfen, Li Zaiquan, Tang Chaoshu. Ameliorative effects of adrenomedullin on rat cardiac sarcoplasmic reticulum injured by isoproterenol. Acta Physiol Sin 2001; 53 (5): (in Chinese with English abstract).