过刊浏览

大鼠杏仁核5-HT_(3)受体参与免疫调制

许德义, 贾宏彬

东南大学基础医学院药理学教研室.江苏,南京 210009

摘要

实验通过大鼠侧脑室和杏仁核给予5-HT_(3)受体激动剂1-phenylbiguanide(PBG),用~(3)H-TdR掺入法测定脾细胞丝裂原刺激增殖效应,用活化脾细胞增殖法测定IL-2生成,MTT法测定自然杀伤细胞活性和用放射免疫测定血浆皮质酮水平,以探讨大鼠杏仁核5-HT_(3)受体在免疫调控中的作用。

关键词： 杏仁核; 脾细胞增殖; IL-2; 5-HT3受体; 神经免疫调制

5-HT_(3) receptors in amygdala mediate neuroimmunomodulation in rats

Xu Deyi, Jia Hongbin

Department of Pharmacology,School of Basic Medical Science,Southeast University.Nanjing 210009,Jiangsu

Abstract

The present study was to explore the possible immunomodulatory role of 5-HT_(3) receptors in the amygdala in rats. Concanovalin A (Con A)- and lipopolysaccharide (LPS)-stimulated splenocyte proliferation response (SPR), production of IL-2, activity of natural killer (NK) cells and serum cortisol were measured by ~(3)H-TdR incorporating method, MTT method and RIA, respectively.

Key words: Amygdala;Splenocyte proliferation response;IL-2;5-HT_(3) receptor;Neurimmunomodulation

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

许德义, 贾宏彬. 大鼠杏仁核5-HT_(3)受体参与免疫调制[J]. 生理学报 2001; 53 (5): .

Xu Deyi, Jia Hongbin. 5-HT_(3) receptors in amygdala mediate neuroimmunomodulation in rats. Acta Physiol Sin 2001; 53 (5): (in Chinese with English abstract).