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过氧亚硝基阴离子诱导离体兔肺动脉舒张反应的特性

谷振勇, 凌亦凌, 李淑瑾, 孟爱宏, 张君岚

河北医科大学病理生理教研室.河北,石家庄 050017

摘要

实验用离体血管环张力测定技术,观察过氧亚硝基阴离子(ONOO~(-))对离体预收缩的兔肺动脉的舒张反应、肺动脉内皮细胞对舒张反应的影响,并初步探讨其病理意义。结果表明,ONOO~(-)对肺动脉的舒张作用较弱,此作用受到内皮细胞的抑制性调节并有快速去敏性。

关键词： 过氧亚硝基阴离子; 肺动脉; 舒张反应; 快速去敏性

Properties of peroxynitrite-induced relaxation in rabbit pulmonary artery in vitro

Gu Zhenyong, Ling Yiling, Li Shujin, Meng Aihong, Zhang Junlan

Department of Pathophysiology,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

These results suggest that ONOO~(-) causes weak relaxation in pulmonary artery, which is down regulated by endothelium and is of tachyphylaxis.

Key words: Peroxynitrite;Pulmonary artery;Relaxation;Tachyphylaxis

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引用本文：

谷振勇, 凌亦凌, 李淑瑾, 孟爱宏, 张君岚. 过氧亚硝基阴离子诱导离体兔肺动脉舒张反应的特性[J]. 生理学报 2001; 53 (4): .

Gu Zhenyong, Ling Yiling, Li Shujin, Meng Aihong, Zhang Junlan. Properties of peroxynitrite-induced relaxation in rabbit pulmonary artery in vitro. Acta Physiol Sin 2001; 53 (4): (in Chinese with English abstract).