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脑预缺血引起大鼠海马细胞膜腺苷受体数量和亲和力升高及其对神经元的保护作用

周爱民, 李清君, 陈晓玲, 李文斌

河北医科大学基础医学研究所病理生理研究室.河北,石家庄 050017

摘要

脑预缺血处理可使大鼠海马细胞膜ADO受体数量增多,亲和力增强,并能对抗损伤性缺血引起的ADO受体数量减少,提示腺苷受体数量及亲和力的变化在脑缺血耐受形成过程中发挥了重要的作用。

关键词： 缺血; 预缺血处理; 腺苷; 腺苷受体; 海马; 脑

Increase in amount and affinity of adenosine receptor in rat hippocampal cellular membranes induced by cerebral ischemic preconditioning and its protective effects on the neurons

Zhou Aimin, Li Qingjun, Chen Xiaoling, Li Wenbin

Department of Pathophysiology,Institute of Basic Medicine,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

The results showed that cerebral ischemic preconditioning increased the amount and affinity of ADO receptor in hippocampal cellular membranes, and resisted the down-regulating of ADO receptor caused by severe ischemia, suggesting an important role of the increase in amount and affinity of ADO receptor in the induction of brain ischemic tolerance.

Key words: Ischemia;Ischemic preconditioning;Adenosine;Adenosine receptor;Hippoca mpus;Brain

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引用本文：

周爱民, 李清君, 陈晓玲, 李文斌. 脑预缺血引起大鼠海马细胞膜腺苷受体数量和亲和力升高及其对神经元的保护作用[J]. 生理学报 2001; 53 (4): .

Zhou Aimin, Li Qingjun, Chen Xiaoling, Li Wenbin. Increase in amount and affinity of adenosine receptor in rat hippocampal cellular membranes induced by cerebral ischemic preconditioning and its protective effects on the neurons. Acta Physiol Sin 2001; 53 (4): (in Chinese with English abstract).