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当归对高脂血清所致ECV_(304)细胞损伤的保护作用

王保华, 欧阳静萍, 刘永明, 魏蕾, 杨静薇

湖北医科大学病理生理教研室.湖北,武汉 430071

摘要

实验观察了高脂血清对培养的人脐静脉内皮细胞(ECV_(304))的损伤及传统中药当归的保护作用,以探讨当归的抗动脉粥样硬化作用及其可能机制。

关键词： 当归; 血管内皮细胞; 超微结构; ICAM-1; NO; TGFβ1; bFGF; 动脉粥样硬化

Protective effect of angelica on ECV_(304) from injury induced by hyperlipidemic serum in vitro

Wang Baohua, Ouyang Jingping, Liu Yongming, Wei Lei, Yang Jingwei

Department of Pathophysiology,Hubei Medical University.Wuhan 430071,Hubei

Abstract

The aim of this article was to examine the protective effect of Chinese traditional medicine Angelica on human umbilical vein endothelial cells (HUVECs, ECV_(304)) from injury induced by hyperlipidemic serum (HLS) and to study the underlying mechanisms. Microstructures of HUVECs were observed by a scanning electron microscope.

Key words: Angelica;Vascular endothelial cell;Microstructure;ICAM-1;TGF#beta#_(1);bFGF;N0;Atherosclerosis

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引用本文：

王保华, 欧阳静萍, 刘永明, 魏蕾, 杨静薇. 当归对高脂血清所致ECV_(304)细胞损伤的保护作用[J]. 生理学报 2001; 53 (3): .

Wang Baohua, Ouyang Jingping, Liu Yongming, Wei Lei, Yang Jingwei. Protective effect of angelica on ECV_(304) from injury induced by hyperlipidemic serum in vitro. Acta Physiol Sin 2001; 53 (3): (in Chinese with English abstract).