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G#alpha#q/11和PDGF依赖性信号转导通路在大鼠主动脉再狭窄中的作用

汪香婷, 吴立玲, 孙银平, 白桦, 高子芬, 许俊堂

北京大学医学部病理生理教研室.北京 100083；新乡医学院病理生理教研室.河南,新乡 453003；北京大学医学部病理教研室.北京 100083；北京红十字朝阳医院心脏中心.北京 100020

摘要

采用大鼠主动脉球囊内皮剥脱术制备主动脉狭窄模型,观察G#alpha#q/11和PDGF信号转导通路在大鼠主动脉球囊损伤后狭窄时血管平滑肌细胞(VSMC)增殖和迁移中的作用。结果提示,PDGF介导的信号转导通路可能是再狭窄时VSMC增殖的重要信号转导机制。

关键词： 再狭窄; G蛋白; 血小板源生长因子受体; 血管平滑肌细胞

Roles of G#alpha#q/11 mediated- and platelet-derived growth factor mediated-signal transduction pathways in rat aorta restenosis

Wang Xiangting, Wu Liling, Sun Yinping, Bai Hua, Gao Zifen, Xu Juntang

Department of Pathophysiology,Health Science Center,Peking University.Beijing 100083；China；Department of Phathology,Health Science Center,Peking University.Beijing 100083

Abstract

The data suggest that the PDGF-mediated signal transduction pathway plays an important role in VSMC proliferation.

Key words: Restenosis;Gprotein;Vascular smooth muscle cell;Platelet-derived gnoivth factor receptor

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引用本文：

汪香婷, 吴立玲, 孙银平, 白桦, 高子芬, 许俊堂. G#alpha#q/11和PDGF依赖性信号转导通路在大鼠主动脉再狭窄中的作用[J]. 生理学报 2001; 53 (3): .

Wang Xiangting, Wu Liling, Sun Yinping, Bai Hua, Gao Zifen, Xu Juntang. Roles of G#alpha#q/11 mediated- and platelet-derived growth factor mediated-signal transduction pathways in rat aorta restenosis. Acta Physiol Sin 2001; 53 (3): (in Chinese with English abstract).