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孤啡肽对海马IL-1#beta#表达的调节作用

肇晖, 杜莅娜, 姜建伟, 吴根诚, 曹小定

复旦大学医学院医学神经生物学国家重点实验室,神经生物学教研室.上海 200032

摘要

采用原位杂交、免疫荧光双标技术及大鼠创伤应激模型,观察孤啡肽对海马白介素-1#beta#(IL-1#beta#)表达水平的影响。结果提示,海马的IL-1#beta#参与创伤应激介导的免疫反应,孤啡肽的神经免疫调节作用可能是通过作用于海马的中枢神经细胞,抑制IL-1#beta#的合成及释放而完成的。

关键词： 孤啡肽; IL-1β; 神经免疫; 神经元; 星形胶质细胞; 小胶质细胞

Modulatory effect of orphanin FQ on the IL-1#beta# transcripts in hippocampus

Zhao Hui, Du Lina, Jiang Jianwei, Wu Gencheng, Cao Xiaoding

State Key Laboratory of Medical Neurobiology,Medical Center of Fudan University,Department of Neurobiology.Shanghai 200032

Abstract

Based on the results, we conclude that orphanin FQ functions as a neuroimmune modulator, and provokes immune response via mediationn of IL-1#beta# derived from neuron, astrocyte and microglia in hippocampus.

Key words: Orphanin FQ;Macrophage;IL-1#beta#;Neuroimrnunology;Neuron;Astrocyte

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引用本文：

肇晖, 杜莅娜, 姜建伟, 吴根诚, 曹小定. 孤啡肽对海马IL-1#beta#表达的调节作用[J]. 生理学报 2001; 53 (3): .

Zhao Hui, Du Lina, Jiang Jianwei, Wu Gencheng, Cao Xiaoding. Modulatory effect of orphanin FQ on the IL-1#beta# transcripts in hippocampus. Acta Physiol Sin 2001; 53 (3): (in Chinese with English abstract).