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#alpha#_(2)-肾上腺素受体介导大鼠主动脉收缩的特性

吕志珍, 张幼怡, 董尔丹, 韩启德

北京大学第三医院血管医学研究所.北京 100083

摘要

发现在大鼠主动脉中,#alpha#_(1)-AR和#alpha#_(2)-AR均可介导其收缩效应并以#alpha#_(1)-AR的作用为主。#alpha#_(1)-AR可增强#alpha#_(2)-AR介导的收缩效应,而#alpha#_(2)-AR则对#alpha#_(1)-AR介导的收缩效应无影响。在不可逆阻断#alpha#_(1)-AR而保留#alpha#_(2)-AR的条件下,#alpha#_(2)-AR介导的缩血管效应消失,仅在阈值浓度的KCl存在下才能显示,且收缩幅度较对照显著降低。结果表明,在离体大鼠主动脉中存在功能性#alpha#_(2)-AR,#alpha#_(2)-AR的缩血管作用依赖于#alpha#_(1)-AR的激动,其最大收缩反应远远小于#alpha#_(1)-AR。

关键词： 主动脉; 受体; 肾上腺素

Characteristics of #alpha#_(2)-adrenoceptor mediated contractile response in isolated aortae of rats

Lu Zhizhen, Zhang Youyi, Dong Erdan, Han Qide

Institute of Vascular Medicine,Third Hospital,Peking University.Beijing 100083

Abstract

It was found that both #alpha#_(1) and #alpha#_(2)-AR (mainly #alpha#_(1)-AR) mediated the contractile response. While #alpha#_(1)-AR enhanced the contractile response mediated by #alpha#_(2)-AR, #alpha#_(2)-AR had no effect on that mediated by #alpha#_(1)-AR. When #alpha#_(1)-AR was irreversibly blocked and the activity of #alpha#_(2)-AR remained intact, the contractile response mediated by #alpha#_(2)-AR was no longer observed. The contractile response only reappeared in the presence of KCl of the threshold level, and the extent of the maximum contraction decreased, compared with control (with #alpha#_(1)-AR being intract). The results show that there exists a functional #alpha#_(2)-AR in rat aorta, however, the contractile effect of which depends on the stimulation of #alpha#_(1)-AR.

Key words: Aortae;Receptor;Adrenaline

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引用本文：

吕志珍, 张幼怡, 董尔丹, 韩启德. #alpha#_(2)-肾上腺素受体介导大鼠主动脉收缩的特性[J]. 生理学报 2001; 53 (3): .

Lu Zhizhen, Zhang Youyi, Dong Erdan, Han Qide. Characteristics of #alpha#_(2)-adrenoceptor mediated contractile response in isolated aortae of rats. Acta Physiol Sin 2001; 53 (3): (in Chinese with English abstract).