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血管内皮生长因子对猪心肌侧枝血管生成的作用

张端珍, 盖鲁粤, 陈以旺, 范瑞云, 文应峰, 董蔚

解放军总医院心内科.北京 100853；Section of Cardiology,Veterans Affairs Medical Center,50 Irving Street, NW, Washington, DC 20422

摘要

为检测血管内皮生长因子165(VEGF165)能否促进冠状动脉侧枝血管形成,实验在成功制作小型猪慢性心肌缺血模型后,将以复制缺陷重组腺病毒为载体的人VEGF165互补脱氧核糖核酸[(cDNA)Ad-VEGF165]直接注入左回旋支(LCX)分布的缺血心肌内,以心电图门控单光子发射计算机断层摄影和离体冠状动脉造影检测冠状动脉侧枝形成、心肌灌注和功能变化。

关键词： 内皮生长因子; 基因治疗; 缺血性心脏病; 血管生成; 心肌功能; 侧枝循环

Therapeutic angiogenesis with the use of vascula endothelial growth factor 165 gene in the myocardium of miniature swine

Zhang Duanzhen, Gai Luyue, Chen Yiwang, Fan Ruiyun, Wen Yingfeng, Dong Wei

Department of Cardiology,the Chinese PLA General Hospital.Beijing 100853；USA

Abstract

It^s concluded that Ad-VEGF165 can induce collateral vessel development in ischemic myocardium and result in significant improvement in myocardial perfusion and function.

Key words: Endothelial growth factor;Gene therapy;Ischemic heart disease;Angiogenesis;;

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引用本文：

张端珍, 盖鲁粤, 陈以旺, 范瑞云, 文应峰, 董蔚. 血管内皮生长因子对猪心肌侧枝血管生成的作用[J]. 生理学报 2001; 53 (3): .

Zhang Duanzhen, Gai Luyue, Chen Yiwang, Fan Ruiyun, Wen Yingfeng, Dong Wei. Therapeutic angiogenesis with the use of vascula endothelial growth factor 165 gene in the myocardium of miniature swine. Acta Physiol Sin 2001; 53 (3): (in Chinese with English abstract).