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过氧化氢加重铁对心肌的损伤作用及其机制

陈莹莹, 沈岳良, 曹春梅, 徐万红, 钱忠明, 夏强

浙江大学医学院生理教研室.浙江,杭州 310006；香港理工大学应用生物与化学技术系.香港,九龙

摘要

采用Langendorff灌流心脏和酶解分离的心肌细胞为实验模型,研究铁对心肌的损伤作用,以及过氧化氢对铁的心肌作用的影响及其可能机制。结果提示,心肌细胞内铁增加可引起心肌功能受损,H_(2)O_(2)可加重铁对心肌的损伤作用,其主要机制可能与·OH无关,而主要与含巯基的蛋白质受损有关。

关键词： 铁; 心脏; 过氧化氢

Hydrogen peroxide augments the injury effect of iron on the isolated rat heart and cardiomyocytes

Chen Yingying, Shen Yueliang, Cao Chunmei, Xu Wanhong, Qian Zhongming, Xia Qiang

Department of Physiology,Zhejiang University School of Medicine.Hangzhou 310006,Zhejiang；China

Abstract

It is suggested that the functional injury of sulfhydryl group containing proteins may be involved in the augmentation of myocardial injury due to the increase of intracellular iron by hydrogen peroxide, but hydroxyl radicals may not.

Key words: Iron;Head;Hydrogen peroxide

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引用本文：

陈莹莹, 沈岳良, 曹春梅, 徐万红, 钱忠明, 夏强. 过氧化氢加重铁对心肌的损伤作用及其机制[J]. 生理学报 2001; 53 (3): .

Chen Yingying, Shen Yueliang, Cao Chunmei, Xu Wanhong, Qian Zhongming, Xia Qiang. Hydrogen peroxide augments the injury effect of iron on the isolated rat heart and cardiomyocytes. Acta Physiol Sin 2001; 53 (3): (in Chinese with English abstract).