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褪黑素抑制雌二醇诱致的垂体PRL瘤生长与血浆PRL和过氧化脂质含量的关系

高列, 许建萍, 单惠敏, 张荣, 许荣kun

医科院中国协和医科大学基础医学研究所生理研究室.北京 100005；医科院肿瘤医院内科.北京 100021

摘要

雄性Sprangue-Dawley大鼠皮下埋置17-#beta#-雌二醇(17-#beta#-estradiol,E_(2))药泵诱发垂体催乳素(prolactin,PRL)瘤,并每日皮下注射褪黑素(melatonin,MLT),观察MLT对E_(2)诱发PRL瘤生长的影响。MLT抑制E_(2)诱致的PRL瘤生长可能与MLT抑制PRL表达性分泌有关,但与MLT抗氧化作用无关。

关键词： 褪黑素; 垂体催乳素瘤; 17-β-雌二醇; 催乳素; 过氧化脂质

Inhibitory effects of melatonin on the development of 17-#beta#-estradiol induced prolactinoma in relation to plasma prolactin and peroxidative lipid contents

Gao Lie, Xu Jianping, Shan Huimin, Zhang Rong, Xu Rongkun

Department of Physiology,Institute of Basic Medical Sciences,Peking Union Medical College and Chinese Academy of Medical Sciences.Beijing 100005；China

Abstract

The experiments demonstrate that the inhibition of the development of E_(2)-induced prolactinoma by adequate dosage of melatonin may be related to the inhibitory effects of MLT on the secretion of PRL, but not to the antioxidative action of MLT.

Key words: Melatonin;17-#bet#-estradiol;Prolactinoma;Antitumorigenesis;Prolactin

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引用本文：

高列, 许建萍, 单惠敏, 张荣, 许荣kun. 褪黑素抑制雌二醇诱致的垂体PRL瘤生长与血浆PRL和过氧化脂质含量的关系[J]. 生理学报 2001; 53 (3): .

Gao Lie, Xu Jianping, Shan Huimin, Zhang Rong, Xu Rongkun. Inhibitory effects of melatonin on the development of 17-#beta#-estradiol induced prolactinoma in relation to plasma prolactin and peroxidative lipid contents. Acta Physiol Sin 2001; 53 (3): (in Chinese with English abstract).